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Reassortant influenza vaccines control avian influenza.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Scientists have generated reassortant influenza vaccines by reverse genetics that allows utilization of a Differentiating Infected from Vaccinated Animals (DIVA) strategy for the control of avian influenza.
"Vaccination of poultry with inactivated influenza vaccine can be an effective tool in the control of avian influenza (AI). One major concern of using inactivated vaccine is vaccine-induced antibody interference with serologic surveillance and epidemiology. In the United States, low pathogenicity H5 and H7 subtype AI viruses have caused serious economic losses in the poultry industry. Most of these viruses also have the accompanying N2 subtype and no H5N1 or H7N8 subtype AI viruses have been identified in poultry in the U.S.," investigators in the United States report.
"In order to allow the DIVA while maintaining maximum efficacy of the vaccine, we generated reassortant viruses by reverse genetics that contained the same H5 and H7 hemagglutinin (HA) gene as the challenge virus, but a heterologous N1 or N8 neuraminidase (NA) gene," said Chang-Won Lee and colleagues at the .S. Department of Agriculture. "In vaccination-challenge experiments in two-week-old specific pathogen-free chickens, reassortant influenza vaccines (rH5N1 and rH7N8) demonstrated similar antibody profiles and comparable protection rates as vaccines prepared with parent H5N2 and H7N2 viruses."
"Further, we ...
- Fort Dodge Animal Health Announces Licensure of a Reverse Genetics Avian...
- Press release article from: PR Newswire March 30, 2006 700+ words
...H5N3 RG, an inactivated virus reverse genetics avian vaccine to aid in the prevention of avian influenza (AI) caused by the H5N1 virus...protect poultry from the disease. Reverse genetics, a cutting-edge technology...
- Reassortant influenza vaccines control avian influenza.
- Newspaper article from: Health & Medicine Week November 1, 2004 700+ words
...influenza vaccines by reverse genetics that allows utilization...the control of avian influenza. "Vaccination...influenza vaccines by reverse genetics that allows utilization...the control of avian influenza. Vaccine, 2004...subject areas of Avian ...
- Evolution of H5N1 avian influenza viruses in Asia.(highly pathogenic )
- Magazine article from: Emerging Infectious Diseases October 1, 2005 700+ words
...highly pathogenic avian influenza A (H5N1) has recently...viral genes were of avian influenza origin, which indicates...was produced by reverse genetics in anticipation of...Highly pathogenic avian influenza viruses of the H5N...
- University of Maryland Expert: Avian Influenza Transmission.
- News wire article from: AScribe Medicine News Service January 15, 2004 700+ words
...human deaths from an avian influenza in Viet Nam this...uses a cutting edge reverse genetics process to research...is below. TOPIC: Avian influenza transmission - How...With plasmid-based reverse genetics, Perez and his team...
- Chiron to Produce Avian Influenza Vaccine for National Institutes of Health...
- Press release article from: PR Newswire May 27, 2004 700+ words
...pandemic. "The avian influenza outbreaks last winter...against other types of avian influenza, including the strain...the vaccine, using reverse genetics, from seed virus...outbreak of disease. Avian influenza, or "bird flu...
- CHIRON GAINS VACCINE CONTRACT AGAINST AVIAN INFLUENZA STRAIN.
- Magazine article from: BIOWORLD Today Pihl-Carey, Karen May 28, 2004 700+ words
...from a strain of avian influenza that recently surfaced...against other types of avian influenza, including a strain...Chiron will use reverse genetics to make the vaccine...were not disclosed. Avian influenza outbreaks occurred...
- Chiron Gains Vaccine Contract Against Avian Influenza Strain.
- Magazine article from: BIOWORLD Today November 3, 2009 700+ words
...from a strain of avian influenza that recently surfaced...against other types of avian influenza, including a strain...Chiron will use reverse genetics to make the vaccine...were not disclosed. Avian influenza outbreaks occurred...
- Avian influenza virus.(Brief Article)(Book Review)
- Magazine article from: SciTech Book News June 1, 2008 700+ words
9781588299390 Avian influenza virus. Ed. by Erica Spackman. Humana Press Inc. 2008 141...propagating the virus in chicken eggs, wild bird surveillance, and reverse genetics. ([c]20082005 Book News, Inc., Portland, OR)
