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HIV-1 immunogen vaccine plus antiretrovirals promotes virologic control.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Therapeutic immunization with an inactivated HIV-1 immunogen plus antiretrovirals promotes virologic control in asymptomatic HIV-infected subjects.
According to a study from Spain, "To determine whether the addition of an inactivated-gp120-depleted HIV-1 immunogen to antiretrovirals (ARTs) conferred a beneficial effect on delaying time to virologic failure relative to that obtained by ARTs alone, a phase II clinical trial was performed in 243 asymptomatic, ART naive, HIV-1 seropositive adults. The Cox model showed that HIV-1 Immunogen treatment was associated with a 34% decrease in the risk of virologic failure (p=0.056)."
"When the analysis incorporated baseline HIV-RNA stratification the risk of virologic failure in the HIV-1 immunogen arm was significantly reduced a 37% compared to the IFA placebo arm (p=0.034)," stated Eduardo Fernandez-Cruz at the University of Madrid and collaborators throughout Spain. "The data suggest that therapeutic immunization plus antiretrovirals ...
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