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Effects of HPV-18 proteins on keratinocyte gene expression determined.

Obesity, Fitness & Wellness Week

| October 23, 2004 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 OCT 23 - (NewsRx.com & NewsRx.net) -- A number of keratinocyte genes have abnormal expression profiles in the presence of human papillomavirus type 18 (HPV-18) E6 and E7 proteins.

In a study from the United States, the effects of these viral proteins "on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed."

"Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from the native differentiation-dependent HPV enhancer-promoter," explained P.A. Garner-Hamrick and coauthors at Western Michigan University. "Total RNA was isolated…

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Source: HighBeam Research, Effects of HPV-18 proteins on keratinocyte gene expression determined.

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