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Tumor-specific gene therapy targets uterine cervical cancer.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Tumor-specific gene therapy targets uterine cervical cancer.
According to published research from South Korea, "although gene therapies using tissue-specific promoters have been reported to be a promising tool for treating cancers, few studies have explored this possibility for uterine cervical cancer."
"MN/CA9 is a transmembrane glycoprotein that was first identified in the human cervical carcinoma cell line, HeLa. Since MN/CA9 protein is highly expressed in uterine cervical cancer tissues, but not in normal cervix, we constructed a tumor-specific replication-competent adenoviral vector utilizing MN/CA9 promoter (Ad-MN/CA9-E1a), which can replicate only in MN/CA9-expressing cells," explained H.Y. Lim and colleagues, Ajou University, School of Medicine.
"Infection of Ad-MN/CA9-E1a to MN/CA9-positive uterine cervical cancer cells (HeLa, C-33 A and SiHa) resulted in much stronger Ad5 E1a protein expressions compared with MN/CA9-negative cells (SK-RC-29), suggesting a tissue-specific replication of this recombinant adenovirus.
"In vitro cytotoxicity assay revealed that the growth of MN/CA9- positive cells was significantly inhibited with 0.01-1 MOI of Ad-MN/CA9-E1a, but the growth of MN/CA9-negative cells (SK-RC-29) could only be ...
- Tumor-specific gene therapy targets uterine cervical cancer.
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...published their findings in Cancer Gene Therapy (Tumor-specific gene therapy for uterine cervical cancer using MN/CA9-directed replication-competent adenovirus. Cancer Gene Therapy, 2004;11(8):532-538). Additional...
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