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Two serotonin receptor subunit genes cleared in FMS etiology.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Two serotonin receptor subunit genes, HTR3A and HTR3B, don't play any obvious role in the development of fibromyalgia, University of Heidelberg geneticists report.
"The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in numerous human disorders. Dysfunction of serotonergic neurotransmission is thought to play a major role in the pathophysiology of the fibromyalgia syndrome (FMS), which is characterized by non-restorative sleep and severe pain," wrote B. Frank and colleagues.
They examined HTR3A and HTR3B for sequence variations in FMS patients to see if there was any connection to FMS etiology.
"We examined DNA samples from 48 patients with FMS representing sporadic cases by single-strand conformation polymorphism (SSCP) and denaturing high-performance liquid chromatography (dHPLC) analysis, sequenced samples with conspicuous patterns, and performed statistical calculations," the researchers explained.
"HTR3A mutational analysis revealed one novel as well as five known sequence variations. Investigating HTR3B, we detected seven formerly described mutations and one novel sequence variant," they reported.
Frank's team said ...
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Source: HighBeam Research, Two serotonin receptor subunit genes cleared in FMS etiology.