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IGF2 gene Apa I polymorphism not associated with endometriosis susceptibility.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Geneticists in Taiwan have determined that the insulin-like growth factor II Apa I polymorphism isn't associated with susceptibility to endometriosis.
"Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls," said Y.Y. Hsieh and colleagues, China Medical University Hospital.
Their analysis showed no difference in genotype frequencies between the two groups (patients: aa = 25.4%, ab = 57.4%, bb = 17.2%; controls aa = 20.8% ab = 52.8%, bb = 26.4%).
Neither did allele frequencies differ (patients: a = 54.1%, b = 45.9%; controls: a = 47.2%, b = 52.8%).
"Therefore," concluded the researchers, "no indication was found for an ...
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