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Ectopic growths develop autonomic and sensory innervation in rat model.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Ectopic endometrial growths developed an autonomic and sensory innervation in a rat model of the disease.
"Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain. Mechanisms that maintain the ectopic growths and evoke symptoms are poorly understood," wrote K.J. Berkley and colleagues, Florida State University.
"One factor not yet considered is that the ectopic growths develop their own innervation," they noted, and this is what they investigated in their study.
"We used a rat model of surgically induced ENDO whose growths mimic those in women. Furthermore, similar to women with ENDO, such rats exhibit reduced fertility and increased pelvic nociception," Berkley's group explained.
"The ENDO was induced by autotransplanting, on mesenteric cascade arteries, small pieces of uterus that formed vascularized cysts. The cysts and healthy uterus were harvested from proestrous rats and immunostained using the pan-neuronal marker PGP9.5 and specific markers for calcitonin gene-related peptide (CGRP) (sensory C and AS fibers), substance P (SIP) (sensory C and AS fibers), and vesicular monoamine transporter (sympathetic fibers)," they wrote.
Berkley and colleagues reported, "Cysts (like the uterus) were ...
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