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MPA downregulates cytokine gene expression in mouse fibroblast cells.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- According to a study from South Africa, "Although medroxyprogesterone acetate (MPA) is used as an injectable contraceptive, in hormone replacement therapy (HRT) and in treatment of certain cancers, the steroid receptors and their target genes involved in the actions of MPA are not well understood."
In their current study D. Koubovec and colleagues at the University of Stellenbosch in South Africa demonstrated "that MPA, like dexamethasone (dex), significantly represses tumor necrosis factor (TNF)-stimulated interleukin-6 (IL-6) protein production in mouse fibroblast (L929sA) cells."
"In addition," they said, "MPA repressed IL-6 and IL-8 promoter-reporter constructs at the transcriptional level via interference with nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1). Furthermore, like dex, MPA does not affect NFkappaB DNA-binding activity."
The researchers "also observed significant transactivation by MPA of a glucocorticoid response element (GRE)-driven promoter-reporter construct in both L929sA and COS-1 cells."
...- Pernod-Ricard Group Sias-Mpa Acquires Two Production Units in South Africa &...
- Press release article from: Business Wire September 8, 1998 700+ words
...in the Works for China Sias-Mpa, the world leader for fruit...first half of 1997. Sias-Mpa Group also announced that it...has established a position in South Africa with the acquisition of the...the dairy industry. Sias-Mpa will immediately add its own...
- ACC members to discuss common strategy on MPA.
- News wire article from: PTI - The Press Trust of India Ltd. October 23, 2006 700+ words
...differences regarding the (MPA). All Test playing nations have to sign the MPA before the ICC finalises the...launched from next year in South Africa. Lalit Modi, the vice president...spats with the ICC over the MPA and was reported as saying...
- MPA hits Thai DVD piracy.(Brief Article)
- Newspaper article from: Screen Digest November 1, 2001 700+ words
...the Motion Picture Association (MPA) successfully shut down a bootleg...the region. Investigators from MPA (USA; +1/818 995 6600; www...countries, including US, UK and South Africa. According to MPA, approximately 7,000 DVDs were...
- Sias-Mpa Group.
- Newspaper article from: Food & Drink Weekly September 28, 1998 700+ words
Sias-Mpa Group, the world leader for...has established a position in South Africa with the acquisition of the...industry. Additionally, Sias-Mpa expanded its business in Argentina...region. Looking ahead, Sias-Mpa Group plans a short-term...
- Avgold's Target --mining at 2,300 m.(South Africa)
- Magazine article from: Mining Magazine June 1, 2001 700+ words
...how moving away from South Africa's traditional labour...massive mining at depth in South Africa was based on the vision...level gold mining in South Africa. The scale of mining...principal stress of 60 MPa and a 'k-ratio' of...
- Rock drills - made in South Africa. (pneumatic rock drill manufacturer Boart...
- Magazine article from: Mining Magazine March 1, 1995 700+ words
...Top 100 companies in South Africa. An NOSA Five Star rating...machine much used in South Africa, and the S250, a 90...times the average in South Africa for standard pneumatic...cylinder ruptured at 4.5 MPa, ten times more than...
- UK and South Africa attract pirate DVDs.
- Newspaper article from: Screen Digest December 1, 2002 700+ words
Video markets in UK and South Africa are most at risk from counterfeit...Picture Association of America (MPA). UK's Federation Against Copyright...further 46,000 have been seized in South Africa. However, less developed markets...
- Water-power drills in South Africa. (Product & Process News) (Column)
- Magazine article from: Mining Magazine April 1, 1992 700+ words
...mines, such as the gold mines of South Africa, the water used for dust suppression...flammability. It was therefore decided in South Africa to use fluids containing 95...closed circuit at pressures of 15 MPa. The 'hydro-transformer' was...