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Chlamydia trachomatis associated with invasive cervical cancer.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Results of an international study show an association of Chlamydia trachomatis with invasive cervical carcinoma regardless of human papillomavirus status.
J.S. Smith and colleagues at the International Agency for Research on Cancer in Lyon, France, explained, "To determine whether Chlamydia trachomatis infection is consistently associated with an increased risk of invasive cervical carcinoma (ICC) after accounting for the strong effect of human papillomavirus (HPV) infection, a case-control study of 1,238 cases of ICC and 1,100 control women from seven countries was carried out (hospital-based studies in Thailand, the Philippines, Morocco, Peru, Brazil, and population-based studies in Colombia and Spain, all coordinated by the International Agency for Research on Cancer, Lyon, France).
"C. trachomatis serum antibody detection was made by means of a microfluorescence assay," according to the study.
Smith and colleagues reported, "Among HPV DNA-positive cases and controls, the risk of squamous cell ICC was elevated in C. trachomatis seropositive women (OR = 1.8; 95% CI = 1.2-2.7) after adjustment for age, center, oral contraceptive use, history of Pap smears, number of full-term pregnancies, and herpes simplex virus 2 seropositivity.
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