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Rat study suggests L-leucine, taken orally during pregnancy, doesn't harm fetus.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- A study conducted in pregnant rats indicates that L-leucine, taken orally, doesn't affect pregnancy outcome and doesn't harm the fetus.
"L-Leucine, an essential amino acid, is one of the most popular ingredients in dietary supplements. To investigate a possibility of its embryo-fetal toxicity in rats, 11- to 12-week old dams were orally administered an aqueous solution of L-leucine at doses of 300 or 1000 mg/kg body weight on gestational days 7-17. Body weight and feed intake was evaluated throughout the whole course of pregnancy (days 0-20)," said K. Mawatari and colleagues, Ajinomoto Co. Inc., Tokyo, Japan.
The researchers found that the supplemental amounts of the amino acid didn't impact the pregnant rats' body weight, although at the high dose of 1000 mg/kg, they ate slightly more on days 14 and 18.
"Cesarean section (day 20) revealed no influences on the litter size and weight of live-born fetuses, the number of corpora lutea, implantation index, or the quality of placenta, and the minor increase in feed intake was considered irrelevant to the pregnancy outcomes," reported the Ajinomoto quality assurance team.
They also evaluated the "fetuses ... in a battery of external, visceral, and skeletal examinations. No effects of ...
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Source: HighBeam Research, Rat study suggests L-leucine, taken orally during pregnancy, doesn't...