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Upregulation of uPA by HER-2/neu appears to occur in early stage disease.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Upregulation of urokinase plasminogen activator by the HER-2/neu oncogene appears to occur in the early stage of cervical cancer in patients, according to recent research.
"It has been suggested that urokinase plasminogen activator (uPA) in cancer cells is upregulated by the p185 kD form of the HER-2/neu oncogene," said obstetrician/gynecologists at Long Island Jewish Medical Center, New York.
D.N. Contreras and colleagues investigated whether "the extracellular domain of HER-2/neu, the p105 fraction, which is found in the circulation, has any regulatory influence on uPA in patients with cervical cancer."
According to their report, "Levels of uPA and p105 HER-2/neu were determined in blood from age-matched controls and patients with early and advanced cervical cancer. In the patients with cervical cancer, samples were obtained before treatment only."
"No significant increase in either uPA or HER-2/neu was seen in the patients before their treatment for cervical cancer. Additionally, correlation analysis of circulating uPA and HER-2/neu against each other in both the controls and cervical cancer indicated no relationship except in early stage disease," wrote ...
- Micrometastases found despite negative nodes. (Early-Stage Cervical Cancer).
- Magazine article from: OB GYN News Bates, Betsy December 15, 2002 700+ words
...micrometastases in the lymph nodes of 14% of 132 early-stage cervical cancer patients who had been categorized as having...closely resembles the recurrence rate [of early-stage cervical cancer] of 15%," said Dr. Dizon, a visiting...
- Human papillomavirus-DNA denotes the outcomes of early-stage cervical cancer.
- Newspaper article from: Drug Week November 19, 2004 700+ words
...denotes the outcomes of early-stage cervical cancer. According to a study...a prognostic factor in early-stage cervical cancer and was associated with...the clinical outcome in early-stage cervical carcinomas. Int...
- A Shot in the Arm Against Early Stage Cervical Cancer.
- Press release article from: Business Wire February 18, 2008 700+ words
...international research, women remain at risk of developing cervical cancer since the virus that causes the cancer persists," says...vaccine was found to be safe in women with advanced metastatic cervical cancer. Of seven stable patients, three showed reductions in...
- National Cervical Cancer Coalition Stresses Importance Of Screening And...
- Press release article from: PR Newswire January 26, 2006 700+ words
...important to remember that cervical cancer is a preventable disease...the best means of detecting cervical cancer at an early stage, vaccines in late-stage...the single known cause of cervical cancer. Two forms of the virus...
- Cervical Cancer and Pap Smears.
- Magazine article from: The Network News Pearson, Cindy September 1, 1999 700+ words
...woman's immune system is compromised, cervical cancer progresses very slowly and can be detected...exist for pre-cancerous conditions and cervical cancer diagnosed at an early stage. And yet cervical cancer is the leading cause of cancer-related...
- A better Pap smear for cervical cancer.
- Newspaper article from: Medical Update Brown, Edwin W. September 1, 1996 700+ words
...was introduced, deaths from cervical cancer have decreased by more than...approval to PAP-NET, the cervical cancer test system of Neuromedical...improved chances of detecting cervical cancer at an early stage, when almost all cases are...
- TREATMENT ALERT ISSUED FOR CERVICAL CANCER DRAMATIC IMPROVEMENT USING CHEMO,...
- Newspaper article from: Seattle Post-Intelligencer (Seattle, WA) February 23, 1999 700+ words
...studies, said two-thirds of women with cervical cancer have not had regular Pap smears...woman's chances of beating advanced cervical cancer. Standard therapy for early-stage cervical cancer is surgery. The New England Journal...
- Cancer before 30? Cervical cancer at 22? Ovarian at 29? It's not supposed to...
- Magazine article from: Marie Claire Polaneczky, Ronnie May 1, 2002 700+ words
...disease that is a major risk factor for cervical cancer. I didn't even know I had it, because...thing, and look what happened to me. Cervical-cancer facts * WARNING SIGNS Early-stage cervical cancer is usually asymptomatic, so you may...
