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Study reports "pronounced" chromosomal instability in advanced disease.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Biophysicists in Norway report finding "pronounced" chromosomal instability in advanced cases of cervical cancer.
"Intratumor heterogeneity in chromosomal aberrations is believed to represent a major challenge in the treatment of cancer. The aim of our work was to assess the chromosomal heterogeneity of advanced cervical carcinomas and to distinguish aberrations that had occurred at a late stage of the disease from early events," said H. Lyng and colleagues.
"A total of 55 biopsies, sampled from two to four different sites within 20 tumors, were analyzed by use of comparative genomic hybridization. Heterogeneous aberrations were identified as those present in at least one of the biopsies and which were not seen, nor seen as a tendency, in the others of the same tumor. The homogeneous aberrations were those seen in all biopsies of the tumor," the researchers explained.
They found that "[t]he most frequent homogeneous aberrations were gain of 3q (65%), 20q (65%), and 5p (50%), indicating that these are early events in the development of the disease."
"Chromosomal heterogeneity was observed in 11 tumors," Lyng's team reported. "The most frequent heterogeneous aberrations were loss of 4p14-q25 (60% of 10 cases with this aberration), and gain of 2p22-pter (50% of 6 cases), 11qcen-q13 (33% of 9 cases), and 8q (27% of 11 cases), suggesting that these events promote progression at a later stage.
"Many of the heterogeneous regions contained genes known ...
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Source: HighBeam Research, Study reports "pronounced" chromosomal instability in advanced...