AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Non-European HPV type 16 variants more frequent in invasive disease.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- A study from Italy found non-European variants of human papillomavirus type 16 occurred more frequently in invasive cervical cancer lesions than European variants.
"Human papillomavirus type 16 (HPV-16) classes (E, AA, As, AM Af2) and their variants have different geographic distribution and different degrees of association with cervical lesions. This study was designed to examine HPV-16 variants among Italian women and their prevalence in case patients (affected by invasive cervical carcinoma or cervical intraepithelial neoplasia grade 2-3 and cervical intraepithelial neoplasia grade 1), versus control subjects with normal cervical epithelium (controls)," reported M.L. Tornesello and colleagues.
They tested "90 HPV-16 positive cervical samples from women of Italian Caucasian descent ..., including 36 invasive cervical carcinomas, 21 with cervical intraepithelial neoplasias grade 2-3, 17 with cervical intraepithelial neoplasia grade 1, and 16 controls."
According to the researchers' report, "HPV-16 was detected with an E6/E7 gene-specific polymerase chain reaction, and variant HPV-16 classes and subclasses were identified by direct nucleotide sequencing of the region coding for the E6 and the E7 oncoproteins, the MY09/11-amplified highly conserved L1 region, and the long control region (LCR).
"Among the 90 HPV-16 samples, nine viral variants have been identified belonging to the European (Ep-T350 and E-G350) and non-European (AA and Af-1) branches," the authors said.
Tornesello and team reported, "The E-G350 is the prevalent variant in all analyzed different disease stages being present in 55.5% of ICC, 52.4% of cervical intraepithelial neoplasias 2-3, 47.1% of cervical intraepithelial neoplasia grade 1, and 50.0% of ...
- Research reports from University of Bologna provide new insights into cervical...
- Newspaper article from: Biotech Week July 29, 2009 700+ words
...associated with 13 low-grade cervical intraepithelial neoplasia and 35 high-grade cervical intraepithelial neoplasia," scientists in Bologna, Italy report (see also Cervical Intraepithelial Neoplasia). "Disruption/deletion...
- Study results from Vanderbilt University in the area of cervical...
- Newspaper article from: Vaccine Weekly November 4, 2009 700+ words
...cases of grade 1 cervical intraepithelial neoplasia are found to have...cases of grade 1 cervical intraepithelial neoplasia that display marked...cases with grade 1 cervical intraepithelial neoplasia were classified...
- Studies from Health Center further understanding of cervical intraepithelial...
- Newspaper article from: Cancer Weekly September 1, 2009 700+ words
...alternative treatment for cervical intraepithelial neoplasia II, III.' "This...report (see also Cervical Intraepithelial Neoplasia Therapy). "Her...biopsy revealed cervical intraepithelial neoplasia (CIN) II, III...
- New cervical intraepithelial neoplasia risk factors study findings recently...
- Newspaper article from: Cancer Vaccine Week April 13, 2009 700+ words
...of high-grade cervical intraepithelial neoplasia in a cohort of Colombian...new data in cervical intraepithelial neoplasia. "Little is known...of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly...
- Research from M. Cruickshank and co-authors provides new data about cervical...
- Newspaper article from: Biotech Week September 2, 2009 700+ words
...if these showed cervical intraepithelial neoplasia grade II or III...cumulative incidence of cervical intraepithelial neoplasia grade II or worse...excision showed no cervical intraepithelial neoplasia (31%; n=156...
- New cervical intraepithelial neoplasia research from University of Ottawa...
- Newspaper article from: Biotech Week September 2, 2009 700+ words
...cumulative incidence of cervical intraepithelial neoplasia grade II or more...Other end points: cervical intraepithelial neoplasia grade III or worse...cumulative incidence of cervical intraepithelial neoplasia grade II or worse...
- What is CIN 2 and how should it be treated? The debate over whether cervical...
- Magazine article from: OB GYN News Nelson, Roxanne June 15, 2006 700+ words
...Experts are divided on how aggressively cervical intraepithelial neoplasia grade 2 should be treated, and on whether...especially in low-risk populations. Cervical intraepithelial neoplasia (CIN) has been regarded as a preinvasive...
- Studies from A.B. Abdul et al further understanding of cervical intraepithelial...
- Newspaper article from: Cancer Weekly October 6, 2009 700+ words
...CIS) to treat cervical intraepithelial neoplasia (CIN) in vivo...report (see also Cervical Intraepithelial Neoplasia). "Microculture...Cisplatin to Treat Cervical Intraepithelial Neoplasia in Female BALB...
Source: HighBeam Research, Non-European HPV type 16 variants more frequent in invasive disease.