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Interlaboratory results support Hybrid Capture 2 HPV test's reliability.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Interlaboratory results show Digene's Hybrid Capture 2 test is reliable for detecting human papillomavirus DNA in liquid cytology specimens.
Researchers at the U.S. National Cancer Institute and at the University of New Mexico "evaluated the interlaboratory reproducibility of the Hybrid Capture 2 (HC2; Digene, Gaithersburg, Maryland), a test for oncogenic human papillomavirus (HPV) DNA, using data from four clinical center (CC) laboratories and the quality control (QC) laboratory participating in the ASCUS (atypical squamous cells of undetermined significance) and LSIL (low-grade squamous intraepithelial lesion) Triage Study (ALTS)."
Philip E. Castle and colleagues explained that "[r]esidual liquid cytology specimens were tested routinely throughout the duration of ALTS at CC laboratories, and a stratified (by time in the study) random sample of specimens was retested by the HPV QC laboratory using equivalent protocols." They had selected 1,175 specimens, of which 1,072 had enough remaining volume to retest.
"The kappa value between all CC laboratories and the HPV QC laboratory was 0.84 (95% confidence interval, 0.78-0.89), with kappa values for individual CCs and the HPV QC laboratory ranging from 0.79 to ...
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