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Development of therapeutic nucleic acids is ongoing.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Researchers with the U.S. National Cancer Institute recently provided an overview on the development of therapeutic nucleic acids to target cervical cancer.
"Cervical cancer is the second most common neoplastic disease affecting women worldwide. Basic, clinical, and epidemiological analyses indicate that expression of high-risk human papillomaviruses (HPVs) E6/E7 genes is the primary cause of cervical cancer and represent ideal targets for the application of therapeutic nucleic acids (TNAs)," wrote J.A. DiPaolo and colleagues.
According to the researchers, "Antisense oligodeoxyribonucleotides (AS-ODNs) and ribozymes (RZs) are the most effective TNAs able to inhibit in vivo tumor growth by eliminating HPV-16 and HPV-18 E6/E7 transcripts. Expression of multiple RZs directed against alternative target sites by triplex expression systems may result in the abrogation of highly variable HPVs.
"More recently," they continued, "RNA interference (RNAi) gene knockdown phenomenon, induced by small interfering RNA (siRNA), has demonstrated its potential value as an effective TNA for cervical cancer.
"siRNA and ...
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...have developed a method of enhancing delivery of a therapeutic nucleic acid. The inventors were issued U.S. Patent No. 7...into a host by administering a nucleic acid encoding a therapeutic nucleic acid along with an agent that modulates Kupffer cell function...
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...About Agilent in Nucleic Acids Agilent, through its Nucleic Acid Solutions Division, is a leading provider of therapeutic nucleic acid development services and manufacturing solutions for the biotech and pharmaceutical industries. The division...
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- Magazine article from: Townsend Letter Krueger, Cindy A. April 1, 2009 700+ words
Worldwide, cervical cancer ranks fifth for cancer mortality...US will have been diagnosed with cervical cancer, and nearly 4,000 will die from it. (2) Estimated new cases of cervical cancer in 2008 are 11,070 and deaths 3...
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- Newspaper article from: NWHRC Health Center - Cervical Cancer March 16, 2005 700+ words
...estimated 10,520 cases of invasive cervical cancer are expected to occur in the U.S...African-American women die from cervical cancer as Caucasian women. Hispanic and...the disease than Caucasian women. Cervical cancer rates also are rising among Vietnamese...
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Cervical cancer is preventable, but it is the second...new cases and 3,870 deaths from cervical cancer occurred in 2008 in the United States...incidence and mortality rates of cervical cancer are higher among women who do not...
- Cervical Cancer; Prevention.
- Newspaper article from: NWHRC Health Center - Cervical Cancer March 16, 2005 700+ words
...tests is the best way of preventing cervical cancer from developing. Reducing or eliminating...associated with the development of cervical cancer can also help prevent it: * Don...genital area. To prevent invasive cervical cancer, the American Cancer Society (ACS...
- Cervical cancer: the sub-Saharan African perspective.(Clinical report)
- Magazine article from: Reproductive Health Matters Anorlu, Rose I. November 1, 2008 700+ words
Abstract: Cervical cancer is the second most common cancer...incidence and mortality rates of cervical cancer have fallen significantly in developed...occur in developing countries. Cervical cancer is the most common cancer among...
Source: HighBeam Research, Development of therapeutic nucleic acids is ongoing.