AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
DMBA-induced mammary tumor progression depends on VEGF-dependent angiogenesis.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- DMBA-induced mammary tumor progression depends on VEGF-dependent angiogenesis.
According to a study from the United States, "preinvasive mammary pathologies in humans and rat chemical carcinogenesis model systems have an increased microvascular density relative to normal tissue. This suggests the possibility of preventing invasive breast cancer by inhibiting angiogenesis. Vascular endothelial cell growth factor (VEGF) is a potent angiogenic growth factor, commonly involved in tumor-induced angiogenesis."
"Here, we show that both VEGF and VEGF receptor 2 (VEGFR2)expression increase with histological progression to invasive disease in the rat 7,12-dimethylbenz[a]anthracene (DMBA) model. Other VEGF receptors, VEGFRI, neuropilin 1 and neuropilin 2, are constitutively expressed throughout progression," said S.C. Heffelfinger and colleagues, University of Cincinnati, Department of Pathology.
"To examine whether VEGF signaling is functionally relevant to tumor-induced endothelial tubule formation in vitro and for tumor formation in vivo, we utilized the VEGFR2 inhibitor, ZD6474. In vitro endothelial cell tubulogenesis induced by isolated mammary organoids or carcinoma in situ from DMBA-treated rats is inhibited by ZD6474 in a ...
- DMBA-induced mammary tumor progression depends on VEGF-dependent angiogenesis.
- Newspaper article from: Obesity, Fitness & Wellness Week October 9, 2004 700+ words
...amp; NewsRx.net) -- DMBA-induced mammary tumor progression depends on VEGF...hypothesis that progression of DMBA-induced preinvasive mammary...Inhibition of VEGFR2 prevents DMBA-induced mammary tumor formation. Lab Invest, 2004...
- RNA inhibition counteracts the growth of human mammary tumor xenografts.
- Newspaper article from: Life Science Weekly October 5, 2004 700+ words
...inhibition counteracts the growth of human mammary tumor xenografts. According to a study from...breast cancer and is believed to enhance mammary tumor progression and metastasis through...suppress macrophage infiltration and mammary tumor growth. Human MCF-7 mammary carcinoma...
- Miniantibodies act as guided missiles targeted to mammary tumor growth.
- Newspaper article from: Biotech Week September 22, 2004 700+ words
...killing radioactive protein lodges in the mammary tumor cells. "The dimeric C6.5K-A binds...kinetics of the HER2 receptor on the mammary tumor cells are favorable to taking up the...beta-emitter is delivered inside the mammary tumor cells, the radiation causes intracellular...
- Enzyme upregulation in the T cells of mammary tumor bearers points to invasion.
- Newspaper article from: Cancer Weekly December 2, 2003 700+ words
...7,12-dimethylbenzanthracene-3 mammary tumor in BALB/c mice, there is progressive...tumors, and we determined that the mammary tumor used in our studies expresses high...to the aberrant MMP-9 secretion by mammary tumor bearers' T cells," researchers said...
- Virus may trigger many cases of breast cancer.(Women's Health)(human mammary...
- Magazine article from: Internal Medicine News Jancin, Bruce February 15, 2007 700+ words
...cancer is caused by infection with human mammary tumor virus, Dr. James F. Holland said...Holland and his colleagues named human mammary tumor virus (HMTV) several years ago has...genetically identical to the mouse mammary tumor virus (MMTV), which is highly prevalent...
- Protection Against Mammary Tumor Growth by Vaccination With Full-Length,...
- Newspaper article from: Vaccine Weekly June 14, 1999 700+ words
...Heilbrun, L.; Jones, R.F. "Protection Against Mammary Tumor Growth by Vaccination With Full-Length, Modified Human...proteins was measured by flow cytomety in transfected murine mammary tumor cell line D2F2. Transmembrane ErbB-2 and ErbB-2A were...
- ErbB2 and TGF-beta cooperate to increase mammary tumor progression.
- Newspaper article from: Cancer Weekly September 14, 2004 700+ words
...NewsRx.net) -- ErbB2 and TGF-beta cooperate to increase mammary tumor progression. "Amplification and overexpression of ErbB2...Cell Cycle (ErbB2 and TGF-beta - A cooperative role in mammary tumor progression? Cell Cycle, 2004;3(5):597-600...
- Escape of mammary cell senescence can be seen in murine mammary tumor model.
- Magazine article from: Women's Health Weekly June 10, 2004 700+ words
...Researchers discuss gene alterations observed in the murine mammary tumor model. "Human mammary epithelial cells emerge spontaneously...scientists in the United States report. "In a mouse mammary tumor model, the spontaneous escape of senescence can be observed...