AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
The cyclooxygenase-2 inhibitor SC-236 stops mammary tumor metastasis.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- The cyclooxygenase-2 inhibitor SC-236 stops mammary tumor metastasis.
"Cyclooxygenase-2 (COX-2) expression is increased in breast cancer and surgery has been shown to increase the growth of metastatic tumours. We investigated the effect of selective COX-2 inhibition on the growth of metastases in either an experimental metastasis model or following excision of a murine primary breast tumor. Fifty thousand 4T1 mammary carcinoma cells were injected into the mammary fat pad of female BALB/c mice," scientists in Ireland report.
"When the mean TD reached 8[+ or -]0.4 mm, tumors were excised and the mice were randomized into two groups (n=12 per group) to receive daily intraperitoneal injections of the selective COX-2 inhibitor, SC-236 or drug vehicle for 14 days. Alternatively, experimental metastases were established by tail-vein injection of 50,000 4T1 cells. Mice received either the selective COX-2 inhibitor, SC-236 or drug vehicle for 14 days (n=12 per group)," wrote G. Roche-Nagle and colleagues, Beaumont Hospital, Royal College of Surgeons in Ireland.
"SC-236 treatment significantly reduced tumor burden, the number and size of spontaneous metastases following primary tumor excision. SC-236 treatment also reduced tumor burden, the ...
- Charter Hospital Closings May Signal Bigger Problems Ahead, Reports Mental...
- Press release article from: PR Newswire February 14, 2000 700+ words
...reports this week's issue of Mental Health Weekly. The stark numbers include 33 hospital...Karen Keiser-Jenkins told Mental Health Weekly last week. Keiser-Jenkins says the...Newswire. For more information on Mental Health Weekly, click on "Newsletters" to receive...
- Problems With Managed Mental Health Program Hold Lesson For Other States,...
- Press release article from: PR Newswire February 15, 1999 700+ words
...contract in state history, this week's issue of Mental Health Weekly reports. Earlier this month, the Montana legislature...Magellan. Center executive director Paul Meyer told Mental Health Weekly that in the last six months, Magellan has denied $500...
- News You Can Use.(Rachel's Environmental and Health Weekly, periodical)(Brief...
- Magazine article from: E Franz, Damon January 1, 2000 700+ words
...weekly publication of the Environmental Research Foundation (ERF). Much like its namesake, Rachel's Environment and Health Weekly sounds the warning about hazardous substances and technologies that threaten human and that environmental health. Rachel...
- Wine slightly better than beer for cardiac health.(Weekly Marketplace)(Brief...
- Magazine article from: Modern Brewery Age February 14, 2005 700+ words
A recent article in the Journal of Thrombosis and Haemostasis determined that drinkers of wine benefit from its cardioprotective effects, more so than those who drink beer or other spirits, and wine drinkers may also live longer. The article is part of a series of papers published in an open forum
- Mistletoe extract augments immune response and reduces tumors.
- Newspaper article from: Immunotherapy Weekly March 19, 2003 700+ words
...application of sME doses greater than 20 microgr per injection. To check the influence of sME treatment on growth of experimental metastases, RAW 117 H 10 lymphosarcoma cells and L-1 sarcoma cells were intravenously inoculated into BALB/c-mice...
- EntreMed Scientists Report Potent Antiangiogenic Effects in Preclinical Studies...
- Press release article from: Business Wire April 14, 1999 700+ words
...for Preclinical Research, Dr. B. Kim Lee Sim today presented an abstract entitled "Potent Inhibition of Experimental Metastases and Primary Tumors by Recombinant Human Endostatin(TM) That is Suitable for Human Use." Dr. Sim reported...
- New prostate cancer study results reported from University of Texas.
- Newspaper article from: Angiogenesis Weekly November 20, 2009 700+ words
...Combination treatment with surgical castration and systemic cav-1 antibody dramatically reduced the number of experimental metastases," wrote M. Watanabe and colleagues, University of Texas (see also Prostate Cancer). The researchers...
- Altor Bioscience Receives Phase II SBIR Grant for Next-Generation Cancer...
- Press release article from: PR Newswire September 20, 2004 700+ words
...exhibits improved pharmacokinetics and potent anti-tumor activity when compared with IL-2 in several different experimental metastases and primary tumor models. The Phase II grant will make it possible for Altor to complete its preclinical evaluations...