AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
RNA inhibition counteracts the growth of human mammary tumor xenografts.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- RNA inhibition counteracts the growth of human mammary tumor xenografts.
According to a study from Austria, "colony-stimulating factor (CSF)-1 is the primary regulator of tissue macrophage production. CSF-1 expression is correlated with poor prognosis in breast cancer and is believed to enhance mammary tumor progression and metastasis through the recruitment and regulation of tumor-associated macrophages. Macrophages produce matrix metalloproteases (MMPs) and vascular endothelial growth factor, which are crucial for tumor invasion and angiogenesis."
"Given the important role of CSF-1, we hypothesized that blockade of CSF-1 or the CSF-1 receptor (the product of the c-fms proto-oncogene) would suppress macrophage infiltration and mammary tumor growth. Human MCF-7 mammary carcinoma cell xenografts in mice were treated with either mouse CSF-1 antisense oligonucleotide for 2 weeks or 5 intratumoral injections of either CSF-1 small interfering RNAs or c-fms small interfering RNAs," described S. Aharinejad and colleagues, Vienna Medical University, Department of Anatomy and Cell Biology.
"These treatments suppressed mammary tumor growth by 50, 45, and 40%, respectively, and selectively downregulated target protein expression in tumor lysates. Host macrophage infiltration; host MMP-12, MMP-2, and vascular ...
- Enzyme upregulation in the T cells of mammary tumor bearers points to invasion.
- Newspaper article from: Cancer Weekly December 2, 2003 700+ words
...dimethylbenzanthracene-3 mammary tumor in BALB/c mice, there...including PGE(2), GM-CSF, and phosphatidyl serine...determined that the mammary tumor used in our studies...MMP-9 secretion by mammary tumor bearers' T cells...
- Miniantibodies act as guided missiles targeted to mammary tumor growth.
- Newspaper article from: Life Science Weekly September 21, 2004 700+ words
...killing radioactive protein lodges in the mammary tumor cells. "The dimeric C6.5K-A binds...kinetics of the HER2 receptor on the mammary tumor cells are favorable to taking up the...beta-emitter is delivered inside the mammary tumor cells, the radiation causes intracellular...
- Virus may trigger many cases of breast cancer.(Women's Health)(human mammary...
- Magazine article from: Internal Medicine News Jancin, Bruce February 15, 2007 700+ words
...cancer is caused by infection with human mammary tumor virus, Dr. James F. Holland said...Holland and his colleagues named human mammary tumor virus (HMTV) several years ago has...genetically identical to the mouse mammary tumor virus (MMTV), which is highly prevalent...
- DMBA-induced mammary tumor progression depends on VEGF-dependent angiogenesis.
- Newspaper article from: Drug Week October 8, 2004 700+ words
...NewsRx.com & NewsRx.net) -- DMBA-induced mammary tumor progression depends on VEGF-dependent angiogenesis. According...Investigation (Inhibition of VEGFR2 prevents DMBA-induced mammary tumor formation. Lab Invest, 2004;84(8):989-998...
- Protection Against Mammary Tumor Growth by Vaccination With Full-Length,...
- Newspaper article from: Vaccine Weekly June 14, 1999 700+ words
...Heilbrun, L.; Jones, R.F. "Protection Against Mammary Tumor Growth by Vaccination With Full-Length, Modified Human...proteins was measured by flow cytomety in transfected murine mammary tumor cell line D2F2. Transmembrane ErbB-2 and ErbB-2A were...
- ErbB2 and TGF-beta cooperate to increase mammary tumor progression.
- Newspaper article from: Cancer Weekly September 14, 2004 700+ words
...NewsRx.net) -- ErbB2 and TGF-beta cooperate to increase mammary tumor progression. "Amplification and overexpression of ErbB2...Cell Cycle (ErbB2 and TGF-beta - A cooperative role in mammary tumor progression? Cell Cycle, 2004;3(5):597-600...
- Escape of mammary cell senescence can be seen in murine mammary tumor model.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...Researchers discuss gene alterations observed in the murine mammary tumor model. "Human mammary epithelial cells emerge spontaneously...scientists in the United States report. "In a mouse mammary tumor model, the spontaneous escape of senescence can be observed...
- A Rat Mammary Tumor Model Induced by the Organophosphorous Pesticides Parathion...
- Magazine article from: Environmental Health Perspectives Cabello, Gertrudis Valenzuela, Mario Vilaxa, Arnaldo Duran, Viviana Rudolph, Isolde Hrepic, Nicolas Calaf, Gloria May 1, 2001 700+ words
...06 for atropine in combination with eserine, and 2.39 [+ or -] 0.29 for atropine with malathion, and there was no mammary tumor formation. These results indicate that organophosphorous pesticides induce changes in the epithelium of mammary gland influencing...
