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Prolactin acts as a potent survival factor for human cell lines.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- The protein hormone prolactin, associated with stimulating lactation, protects human breast cancer cell lines from apoptosis, researchers in the U.K. report.
Citing a large epidemiologic study of breast cancer that showed "strong associations" between prolactin and breast cancer risk, C.C. Perks and colleagues at the Bristol Royal Infirmary & General Hospital investigated prolactin's role in the growth and survival of breast cancer cells in established models of apoptosis.
"We showed that prolactin had no effect on the metabolic activity or total cell number of any cell lines. We confirmed endogenous prolactin production by these cells and that the levels varied," stated the research team.
"In the presence of a prolactin-neutralizing antibody, each of the cell lines responded with the induction of apoptosis as opposed to growth inhibition. The sensitivity of the cell lines to the physiological inducer of apoptosis, C2-ceramide, appeared relative to the levels of endogenous prolactin that they contained," reported Perks and coworkers.
Exogenous prolactin, they found, "acted as a potent survival factor against apoptosis in all the ...
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