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Meta-analysis supports IGF-I and IGFBP-3 level link with premenopausal cancer.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Results of a meta-analysis suggest an association between levels of insulin-like growth factor (IGF)-I and IGF-binding proteins and development of premenopausal breast cancer.
"IGFs are peptide hormones involved in the regulation of cell proliferation, differentiation, and apoptosis. IGFs are regulated by endocrine and paracrine mechanisms; however, their action in tissue is determined by circulating levels and local production of IGFs and IGF-binding proteins (IGFBPs). Some, but not all, epidemiologic studies have associated high circulating levels of IGF-I with increased risk of breast cancer among premenopausal women," wrote R.H. Shi and colleagues, Louisiana State University (LSU).
Shi's team performed a meta-analysis of studies in the literature "[t]o evaluate the overall association of IGF-I and IGFBP-3 levels with breast cancer risk." Sixteen epidemiologic and clinical studies were evaluated.
"Analyses were performed for all women as well as for pre- and postmenopausal women separately. Hedges' standardized mean differences (HSMDs) and odds ratios (ORs) were used to estimate the effect of IGF-I and IGFBP-3," the researchers explained.
"Data analysis showed that circulating levels of lGF-I were not significantly higher in breast cancer patients than in controls for all women and for the postmenopausal group (HSMD = 0.024 and ...
- IGF expression higher in tissue of women at high breast cancer risk.
- Newspaper article from: Immunotherapy Weekly May 26, 2004 700+ words
...insulin-like growth factor (IGF)-system plays a role in breast cancer susceptibility as well as in growth...studies aimed at understanding IGF as a breast cancer risk factor, the relationship between IGF-systems in serum and tissues...
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- Newspaper article from: Proteomics Weekly March 15, 2004 700+ words
...growth factor I (IGF-I) receptor...activator in breast cancer is associated...observed that IGF-IR and uPA...and 55% of breast cancer by screening...large number of breast cancer patients by inhibiting the IGF-IR and ultimately...
- IGF-binding protein induces apoptosis in breast cancer cells.
- Newspaper article from: Cancer Weekly May 25, 2004 700+ words
...like growth factor (IGF)-independent manner...pathway in MCF-7 human breast cancer cells. "Induction...DNA synthesis in an IGF-IGF receptor axis...negative regulator of breast cancer cell growth, independent of the IGF-IGF receptor axis...
- Cathepsin D decrease in breast cancer mediated by IGF-II receptor.
- Newspaper article from: Cancer Weekly July 13, 2004 700+ words
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...approaches target blocking the IGF receptor or inhibition of post...form of insulin growth factor (IGF- II) the anti-tumor benefit...Depleting soluble ligand (IGF-II) in solid tumor (human breast cancer xenograft) by ligand-specific...
- IGF LEVELS KEY IN DIAGNOSING BREAST CANCER.
- Magazine article from: Health Products Business February 1, 2001 700+ words
...growth of breast, endometrial and prostate tumors. IGF-I levels were recently isolated as a potential...cancer not only by inhibiting cell growth induced by IGF-I, but also by effectively lowering IGF blood levels. Lycopene is known to reduce prostate...
- Reduced expression of IGF-IR leads to a more metastatic phenotype.(insulin-like...
- Magazine article from: Women's Health Weekly January 23, 2003 700+ words
...like growth factor system in breast cancer. Alterations in insulin-like growth factor I receptor (IGF-IR) have been associated with breast cancer metastasis; however, the specific role played by the IGF-IR in this process remains...
- Reduced expression of IGF-IR leads to a more metastatic phenotype.
- Newspaper article from: Genomics & Genetics Weekly January 24, 2003 700+ words
...like growth factor system in breast cancer. Alterations in insulin-like growth factor I receptor (IGF-IR) have been associated with breast cancer metastasis; however, the specific role played by the IGF-IR in this process remains...
Source: HighBeam Research, Meta-analysis supports IGF-I and IGFBP-3 level link with...