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Mammaglobin-A vaccine has therapeutic potential.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- A mammaglobin-A vaccine has potential as a treatment for certain breast cancers, results from a study in mice suggest.
The breast cancer-associated antigen mammaglobin-A has been found in 80% of breast tumors, but not in normal breast cells.
T. Mohanakumar, PhD, and colleagues demonstrated in a mouse model of human breast cancer that a mammaglobin-A cDNA vaccine reverses tumor growth in breast tumors that express the antigen.
"We developed an in vivo model using human leukocyte antigen-A*0201/human CD8+ (HLA-A2+/hCD8+) double-transgenic mice to define the epitopes and to study the level of protection acquired by mammaglobin-A cDNA vaccination toward mammaglobin-A+/HLA-A2+ breast cancer cell lines," the researchers wrote in the September 15, 2004, issue of the Journal of the National Cancer Institute (JNCI, 2004;96(18):1388-1396).
"Mammaglobin-A epitopes were identified using an HLA class I peptide binding prediction computer program, and their activity was verified using gamma interferon ELISPOT and cytotoxicity assays," the team continued.
First author Kishore Narayanan, Mohanakumar, and colleagues were able to identify "seven mammaglobin-A-derived candidate epitopes that bind the ...
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Source: HighBeam Research, Mammaglobin-A vaccine has therapeutic potential.