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Chemokines linked to breast tumorigenesis.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Several chemokines has been tentatively linked to the pathogenesis of breast cancer.
In a recent study, oncologists in Boston examined "the comprehensive gene expression profiles of each cell type composing normal breast tissue and in situ and invasive breast carcinomas using serial analysis of gene expression."
"Based on these data," M. Allinen and coauthors at the Dana-Farber Cancer Institute "determined that extensive gene expression changes occur in all cell types during cancer progression and that a significant fraction of altered genes encode secreted proteins and receptors."
"Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells," according to the report. "The CXCL14 and CXCL12 chemokines overexpressed in tumor myoepithelial cells and myofibroblasts, respectively, bind to receptors on epithelial ...
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Source: HighBeam Research, Chemokines linked to breast tumorigenesis.