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Spermidine and spermine levels higher in female ALS patients than males.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Study data suggest that regulation of polyamine levels is maintained in end-stage amyotrophic lateral sclerosis, and, interestingly, show that in female patients, spermidine and spermine levels in the ventral horn region are higher than those of males.
T. Ekegren and colleagues, University of Uppsala Hospital, Sweden, measured postmortem putrescine, spermidine, and spermine (all polyamines) levels from the spinal cords of seven amyotrophic lateral sclerosis (ALS) patients and seven controls.
According to the researchers, their "method consisted of precolumn derivatization of the polyamines, followed by high-performance liquid chromatography analysis and fluorescence detection."
They determined the polyamines' stability in rat spinal cord over 0-36 hours postmortem and found that the levels of putrescine increased 32%, spermidine by 15%, and spermine by 2%.
"Polyamine levels did not differ significantly between the ALS group and the control group, suggesting a maintained regulation of polyamines in the end stage of the disease," Ekegren and associates said.
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Source: HighBeam Research, Spermidine and spermine levels higher in female ALS patients than...