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Mom's atopic disease modifies effects of prenatal risk factors on exhaled NO.

Women's Health Weekly

| October 07, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 OCT 7 - (NewsRx.com & NewsRx.net) -- According to a study from Switzerland, maternal atopic disease modifies the effects of prenatal risk factors on exhaled nitric oxide in infants.

U. Frey and colleagues, University Hospital of Bern, measured exhaled nitric oxide (eNO) in healthy unselected infants to see if this could be associated with maternal atopic disease and environmental exposures both pre- and postnatally.

"Tidal eNO was measured in 98 healthy, unsedated infants (35 from mothers with atopy) (mean age [+ or -] SD, 36.0 [+ or -] 6.2 days) and was compared with histories taken in standardized interviews," wrote the researchers.

They reported that "eNO was higher in males compared with females (117.7 vs. 14.6 ppb, p=0.042) and infants exposed to postnatal maternal smoking (+4.4 ppb, p=0.027), adjusting for weight and tidal breathing parameters."

Additionally, tobacco exposure in utero "was associated with higher eNO (+12.0 ppb, p=0.01) in infants of mothers with asthma and lower eNO (-5.7 ppb) in infants of mothers without asthma (p for interaction

And, according to the study, "[c]offee consumption in pregnancy decreased eNO (-6.0 ppb, p=0.008) only in children of mothers with atopy (p for interaction = 0.015). Paternal atopy had no influence."

Frey and ...

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