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Immunization with Listeria controls virus load after FIV challenge.
2004 OCT 7 - (NewsRx.com & NewsRx.net) -- Oral immunization with recombinant Listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus.
"Recombinant Listeria monocytogenes has many attractive characteristics as a vaccine vector against human immunodeficiency virus (HIV). Wild-type and attenuated Listeria strains expressing HIV Gag have been shown to induce long-lived mucosal and systemic T-cell responses in mice. Using the feline immunodeficiency virus (FIV) model of HIV we evaluated recombinant L. monocytogenes in a challenge system," scientists in the United States report.
"Five cats were immunized with recombinant L. monocytogenes that expresses the FIN Gag and delivers an FIV Env-expressing DNA vaccine (LMgag/pND14-Lc-env)," said Rosemary Stevens and collaborators at North Carolina State University. "Control cats were either sham immunized or immunized with wild-type L. monocytogenes (LM-wt). At 1 year after vaginal challenge, provirus could not be detected in any of the nine tissues evaluated from cats immunized with the recombinant bacteria but was detected in at least one tissue in 8 of 10 control animals."
"Virus was isolated from bone marrow of four of five LMgag/pND14-Lc-env-immunized cats by use of a stringent coculture system but required CD8+ T-cell depletion, indicating CD8+ T-cell suppression of virus replication," reported Stevens and her coauthors. "Control animals had an inverted CD4:CD8 ratio in mesenteric lymph node and ...
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Source: HighBeam Research, Immunization with Listeria controls virus load after FIV challenge.