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Novel immunogenic proteins of Shigella flexneri identified.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have identified novel immunogenic proteins of Shigella flexneri 2a using proteomic methodologies.
"Shigella species are one of the most important etiological factors for people who are living in developing countries and travelers to tropical countries. High priority has been given by the World Health Organization to the development of vaccines to control shigellosis caused by these bacteria," scientists writing in the journal Vaccine report.
"However, information regarding to profile of immunogenic proteins of Shigella is not available now," said Xuanxian Peng and colleagues at Xiamen University. "In the present study, sub-immunoproteomics was applied to screen novel immunogenic proteins that could be reacted with antisera produced by challenge of a whole bacterium. Our results indicated that 13 immunogens were identified, in which seven proteins and six proteins from outer membrane and soluble proteome, respectively. Of the 13 proteins, 12 showed to be novel immunogens."
The investigators ...
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Source: HighBeam Research, Novel immunogenic proteins of Shigella flexneri identified.