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Phosphoprotein binding site on Sendai virus protein mapped.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have mapped the phosphoprotein binding site on Sendai virus NP protein assembled into nucleocapsids.
According to a study from the United States, "To catalyze RNA synthesis, the Sendai virus P-L RNA polymerase complex first binds the viral nucleocapsid (NC) template through an interaction of the P subunit with NP assembled with the genome RNA. For replication, the polymerase utilizes an NP[subscript]0-P complex as the substrate for the encapsidation of newly synthesized RNA, which involves both NP-RNA and NP-NP interactions. Previous studies showed that the C-terminal 124 amino acids of NP (aa 401-524) contain the P-NC binding site."
"To further delineate the amino acids important for this interaction, C-terminal truncations and site-directed mutations in NP were characterized for their replication activity and protein-protein interactions," said Bayram Cevik and colleagues at the University of Florida. "This C-terminal region was found in fact to be necessary for several different protein interactions. The C-terminal 492-524 aa were nonessential for the complete activity of the protein."
"Deletion of amino acids 472-491, however, abolished replication activity due to a specific defect in the ...
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Source: HighBeam Research, Phosphoprotein binding site on Sendai virus protein mapped.