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Glycan arrays lead to discovery of autoimmunogenic activity of SARS-CoV.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Glycan arrays lead to the discovery of autoimmunogenic activity of SARS-CoV.
"Using carbohydrate microarrays, we characterized the carbohydrate binding activity of SARS-CoV neutralizing antibodies elicited by an inactivated SARS-CoV vaccine. In these antibodies, we detected undesired autoantibody reactivity specific for the carbohydrate moieties of an abundant human serum glycoprotein asialo-orosomucoid (ASOR). This observation provides important clues for the selection of specific immunologic probes to examine whether SARS-CoV expresses antigenic structures that mimic the host glycan," researchers in the United States and China report.
"We found that lectin PHA-L (Phaseolus vulgaris L.), which is specific for a defined complex carbohydrate of ASOR, stained the SARS-CoV-infected cells specifically and intensively," said Denong Wang at Stanford University in the U.S. and Jiahai Lu at Sun Yat-sen University in China. "Taken together, we present immunologic evidence that a carbohydrate structure of SARS-CoV shares antigenic ...
- DNA vaccines target nucleocapsid protein of SARS coronavirus.
- Newspaper article from: Vaccine Weekly June 30, 2004 700+ words
...for control of infection with SARS-CoV." Kim and associates published...under the major subject areas of SARS Vaccine, SARS Therapy, DNA Vaccine, Vaccine...This article was prepared by Vaccine Weekly editors from staff and other reports...
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- Newspaper article from: Vaccine Weekly July 14, 2004 700+ words
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- Antibody to S1 protein neutralizes SARS coronavirus.
- Newspaper article from: Vaccine Weekly May 5, 2004 700+ words
...article comes under the major subject areas of SARS, SARS Therapy, SARS Vaccine, Vaccine Development, Pharmaceutical...Proteomics, and Virology. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright...
- China's recent SARS outbreak raises concerns about biosafety.
- Newspaper article from: Vaccine Weekly July 28, 2004 700+ words
...timing of the use of inactivated SARS coronavirus in the general...used to inactivate the live SARS virus. At the same time...were admitted to designated SARS facilities. In addition...This article was prepared by Vaccine Weekly editors from staff and other...
- SARS coronavirus spike protein protectively immunizes mice.
- Newspaper article from: Vaccine Weekly July 7, 2004 700+ words
...under the major subject areas of SARS Vaccine, SARS, Vaccine Development, Immunology...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
- Experimental SARS vaccine shows promise in mice.
- Newspaper article from: Vaccine Weekly April 21, 2004 700+ words
...genetic sequences of the SARS virus in an effort to find drugs to treat SARS or develop a vaccine to prevent...are suspected of spreading SARS to humans, although the...This article was prepared by Vaccine Weekly editors from staff and other...
- SARS antibody sent to China for preclinical testing.
- Newspaper article from: Vaccine Weekly May 26, 2004 700+ words
...the fully human antibody to SARS developed by Medarex and MBL...trials for a vaccine to prevent SARS. The vaccine development...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
- SARS vaccine phase I clinical testing commences.
- Newspaper article from: Vaccine Weekly March 3, 2004 700+ words
...news article entitled "China to test SARS vaccine on humans, "SARS originally emerged in south China's...Hepatitis A and Hepatitis B, influenza and SARS. This article was prepared by Vaccine Weekly editors from staff and other reports...