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Novel route to an anti-ricin vaccine reported.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Insertional mutagenesis of ricin A chain leads to a novel route toward an anti-ricin vaccine.
According to recent research from England, "The insertion of a specific 25-residue internal peptide into ricin toxin A chain (RTA) reduced the catalytic activity of this protein (approx)300-fold. Directed proteolytic cleavage of the peptide insert essentially restored catalytic activity of the resulting two peptide A chains to normal levels. Ricin holotoxin containing unprocessed mutant A chain was not toxic to cultured mammalian cells, due to enhanced proteasomal degradation, nor was it toxic when injected into rats at a concentration that is lethal in the case of native ricin."
"Rats treated in this way were completely resistant to native ricin when subsequently challenged with a potentially lethal dose of the toxin," said Catherine J. Marsden and colleagues at the University of Warwick. "These ricin-resistant animals had a significant ...
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...the development of its recombinant ricin vaccine program, has received a $2.6 Million...for intranasal and oral delivery of ricin vaccine directed at ease of administration...over a six month period. This novel ricin vaccine has been developed in the laboratory...
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...blood may prevent death but not tissue damage in the lungs, intestine and elsewhere." This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- License agreement executed for rights to ricin vaccine technology.
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...ability to induce vascular leak syndrome (VLS). Complete elimination of both types of toxicity is likely to render this vaccine very safe at effective doses. This article was prepared by Vaccine Weekly editors from staff and other reports.
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...its ability to induce vascular leak syndrome. Complete elimination of both types of toxicity is likely to render this vaccine very safe at effective doses. This article was prepared by Vaccine Weekly editors from staff and other reports.
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- Newspaper article from: Vaccine Weekly October 30, 2002 700+ words
...Firan, John R. Fulmer, Stephen L. Ruback; and Dr. Victor Ghetie, professor. The work was supported by a U.S. National Institutes of Health grant. This article was prepared by Vaccine Weekly editors from staff and other reports.
- DOR BioPharma Executes Option for Non-Toxic Ricin Vaccine Technology From...
- Press release article from: Business Wire January 7, 2003 700+ words
...2003 Complements Microvax(TM) Ricin Vaccine Initiative Announced by DOR on Sept...be too toxic for use in humans. The ricin vaccine will be the first in a series of biodefense...which ricin may be used. This novel ricin vaccine has been developed in the laboratory...