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Transgenic tolerized T cells cannot aid B cells upon mucosal challenge.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Transgenic tolerized T cells are unable to help B cells upon mucosal challenge.
"The oral delivery of soluble antigens induces unresponsiveness to systemic challenge that can be demonstrated as a reduced ability of tolerized T cells to support B-cell expansion and antibody production. However, it remains controversial whether previously induced oral tolerance results in suppression or priming, or has no effect on B-cell responses upon oral challenge. Using a double adoptive transfer system, we primed or tolerized T cells (independently of B cells) with a high dose of fed antigen, and examined the ability of these primed or tolerized T cells to support B-cell clonal expansion in response to orally delivered conjugated antigen," investigators in Scotland report.
"We demonstrated directly in vivo that, in contrast to orally primed T cells, transgenic T cells tolerized by feeding a high dose of antigen are incapable of providing cognate help to support B-cell clonal expansion and antibody production in response to oral challenge," said Natalie Kobets and ...
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Source: HighBeam Research, Transgenic tolerized T cells cannot aid B cells upon mucosal...