AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
RelB mediates TNF-induced up-regulation of polymeric Ig receptor.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor.
"Secretory antibodies, which operate in a principally noninflammatory fashion, constitute the first line of acquired immune defense of mucosal surfaces. Such antibodies are generated by polymeric Ig receptor (pIgR)-mediated export of dimeric IgA and pentameric IgM. TNF activates a proinflammatory gene repertoire in mucosal epithelial cells and also enhances pIgR expression," scientists writing in the Journal of Immunology report.
"In this study we show that TNF-induced up-regulation of the human pIgR critically depends on an NF-kappaB site and flanking sequences within a 204-bp region of the first intron in the pIgR gene, a region largely overlapping with a recently characterized IL-4-responsive enhancer," said Hilde Schjerven and colleagues at Rikshospitalet University Hospital. "The intronic NF-kappaB site was rapidly bound by NF-kappaB p65/p50 heterodimers present in nuclear extracts after TNF treatment of HT-29 cells, but a more delayed binding of ROB agreed better with the slow, protein synthesis-dependent, transcriptional activation of the pIgR gene."
"Overexpression of NF-kappaB p65 caused transient up-regulation of a pIgR-derived reporter gene, whereas overexpression of ...
- Research results from University of Montana update understanding of immunology.
- Newspaper article from: Immunotherapy Weekly June 17, 2009 700+ words
"Polymeric Ig receptor (pIgR) is a central player in mucosal immunity that mediates...Cutting Edge: Lung Mucosal Th17-Mediated Responses Induce Polymeric Ig Receptor Expression by the Airway Epithelium and Elevate Secretory IgA Levels...
- Transcriptional regulation of mucosal IgA requires two cell types.
- Newspaper article from: Drug Week May 28, 2004 700+ words
...The epithelial capacity for IgA export is likewise regulated by transcriptional modulation of the level of polymeric Ig receptor. Therefore, transcriptional gene regulation in two different cell types is central for IgA-dependent mucosal...
- Researchers from Erasmus University report on findings in allergies.
- Newspaper article from: Respiratory Therapeutics Week August 17, 2009 700+ words
...preventive and curative effect, as all effects of CTB were abrogated in mice lacking the luminal IgA transporting polymeric Ig receptor," wrote H.H. Smits and colleagues, Erasmus University. The researchers concluded: "Not only do these...
- Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal...
- Magazine article from: Journal of Clinical Investigation Yoshida, Masaru Kobayashi, Kanna Kuo, Timothy T. Bry, Lynn Glickman, Jonathan N. Claypool, Steven M. Kaser, Arthur Nagaishi, Takashi Higgins, Darren E. Mizoguchi, Emiko Wakatsuki, Yoshio Roopenian, Derry C. Mizoguchi, Atsushi Lencer, Wayne I. Blumberg, Richard S. August 1, 2006 700+ words
...known to be transported across epithelial cells into the lumen through an active unidirectional process by the polymeric Ig receptor (pIgR) (4). In addition to sIgA, significant quantities of IgG can also be secreted into the intestinal...
- Study data from University of Nottingham provide new insights into immunology.
- Newspaper article from: Immunotherapy Weekly July 1, 2009 700+ words
...Phe443, lies at the Fc domain interface and has been implicated in the binding of host receptors Fc alpha RI and polymeric Ig receptor (pIgR), as well as IgA-binding proteins produced by certain pathogenic bacteria. Substitutions within the...
- Autologous lymphoma vaccines induce T cell responses against epitopes.
- Newspaper article from: Vaccine Weekly August 4, 2004 700+ words
...Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. "The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific antigen and an attractive target for active immunotherapy...
