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Role of CD8+ T-cell immunity in progression of melanoma reviewed.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients in a recent issue of Clinical Cancer Research.
According to published research from the Netherlands, "Cytotoxic T-cell immunity directed against melanosomal differentiation antigens is arguably the best-studied and most prevalent form of tumor-specific T-cell immunity in humans. Despite this, the role of T-cell responses directed against melanosomal antigens in disease progression has not been elucidated. To address this issue, we have related the presence of circulating melanoma-specific T cells with disease progression and survival in a large cohort of patients with advanced-stage melanoma who had not received prior treatment."
"In 42 (68%) of 62 patients, melanoma-specific T cells were detected, sometimes in surprisingly large numbers," reported Monique van Oijen and colleagues at the Netherlands Cancer Institute. "Disease progression during treatment was more frequent in patients with circulating melanoma-specific T cells, and mean survival of patients with circulating melanoma-specific T cells was equal to the survival of patients without melanoma-specific T cells."
"These data suggest that the induction of melanosomal ...
- Role of CD8+ T-cell immunity in progression of melanoma reviewed.
- Newspaper article from: Immunotherapy Weekly October 6, 2004 700+ words
...specific CD8+ T-cell immunity in disease progression...of Clinical Cancer Research. According...Cytotoxic T-cell immunity directed against...in Clinical Cancer Research (On the role...specific CD8+ T-cell immunity in disease progression...
- CD8+ T-cell immunity to cytomegalovirus reviewed.
- Newspaper article from: Immunotherapy Weekly September 1, 2004 700+ words
...Researchers review CD8+ T-cell immunity to cytomegalovirus in a recent...Human Immunology (CD8+ T-cell immunity to cytomegalovirus. Hum Immunol...University of Birmingham, Cancer Research UK Institute for Cancer Studies...
- Seronegative subjects retain T cell immunity to herpes simplex virus.
- Newspaper article from: Virus Weekly June 10, 2003 700+ words
...possessed HSV-specific T cell immunity but, by multiple...the Fred Hutchinson Cancer Research Center, University...of Immunology (T cell immunity to herpes simplex...Fred Hutchinson Cancer Research Center, 1100 Fairview...
- HER-2/neu antigen promotes specific T-cell immunity in cancer patients.(Brief...
- Newspaper article from: Vaccine Weekly August 7, 2002 700+ words
...lung cancer were able to develop T-cell immunity to HER-2/neu protein, according...would result in the generation of T-cell immunity specific for the HER-2/neu protein...testing for antigen-specific T-cell immunity in peripheral-blood mononuclear cells...
- HER-2/neu antigen promotes specific T-cell immunity in cancer patients.
- Newspaper article from: Cancer Weekly August 6, 2002 700+ words
...lung cancer were able to develop T-cell immunity to HER-2/neu protein, according...would result in the generation of T-cell immunity specific for the HER-2/neu protein...testing for antigen-specific T-cell immunity in peripheral-blood mononuclear cells...
- T cell immunity to cytomegalovirus studied in HIV patients after HAART.
- Newspaper article from: Health & Medicine Week November 29, 2004 700+ words
...human cytomegalovirus-specific T cell immunity in HIV-infected patients in different...long-term non-progressors. "T cell immunity to human cytomegalovirus (HCMV) was...of human cytomegalovirus specific T cell immunity in human immunodeficiency virus infected...
- Method to measure T cell immunity to influenza vaccination developed.
- Newspaper article from: Virus Weekly December 14, 2004 700+ words
...have developed a method to measure T cell immunity to influenza vaccination in children...assay to quantify antigen-specific T cell immunity to influenza A and studied the T cell...Journal of Haematology (Measuring T cell immunity to influenza vaccination in children...
- T cell immunity achieved using transgenic B lymphocytes.
- Newspaper article from: Vaccine Weekly May 19, 2004 700+ words
...2004 MAY 19 - (NewsRx.com & NewsRx.net) -- T cell immunity was achieved using transgenic B lymphocytes. "Adaptive...National Academy of Sciences of the United States of America (T cell immunity using transgenic B lymphocytes. Proc Nat Acad Sci USA...