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DNA-Salmonella vaccine protects against Leishmania major.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination enhances protection against Leishmania major infection in mice.
"Successful resolution of infections by intracellular pathogens requires gamma interferon (IFN-gamma). DNA vaccines promote T helper 1 (Th1) responses by triggering interleukin-12 (IL-12) release by dendritic cells (DC) through Toll-like receptor 9 (TLR9). In humans TLR9 is restricted to plasmacytoid DC," investigators in England report.
"Here we show that DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination, which provides alternative ligands to bind TLR4 on myeloid DC, strongly biases towards Th1 responses compared to vaccination with DNA alone," said Uta G. Lange and colleagues at the University of Cambridge. "This results in higher immunoglobulin G2a (IgG2a) responses compared to IgG1 responses, higher IFN-gamma responses compared to IL-10 CD4+-T-cell responses, and enhanced protection against Leishmania major infection in susceptible BALB/c ...
- DNA-Salmonella vaccine protects against Leishmania major.
- Newspaper article from: Drug Week October 8, 2004 700+ words
...NewsRx.net) -- DNA-Salmonella enterica...enhances protection against Leishmania major infection in mice...interferon (IFN-gamma). DNA vaccines promote T helper...enhanced protection against Leishmania major infection in susceptible...Infection and Immunity (DNA-Salmonella ...
- Selenophosphate synthetase gene from Leishmania major characterized.
- Newspaper article from: Drug Week April 30, 2004 700+ words
...sequence was cloned from Leishmania major by RT-PCR amplification. The DNA sequence was found to...published their study in DNA Sequence (The selenophosphate synthetase gene from Leishmania major. DNA Sequence, 2004;15...
- Leishmania major chromosome 3 contains two gene clusters.
- Newspaper article from: Proteomics Weekly September 1, 2003 700+ words
...NewsRx.net) -- Leishmania major chromosome 3 contains...nucleotide sequence of Leishmania major Friedlin chromosome...binding protein and a DNA primase subunit...Nucleic Acids Research (Leishmania major chromosome 3 contains...
- Immunology of susceptibility and resistance to Leishmania major reviewed.
- Newspaper article from: Vaccine Weekly March 12, 2003 700+ words
...susceptibility and resistance to Leishmania major has been published...mice infected with Leishmania major - involving the early...provides a rationale for DNA vaccines or live...susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol...
- Leishmania major exogenous antigens protects against infection.
- Newspaper article from: Life Science Weekly December 7, 2004 700+ words
...NewsRx.net) -- Immunization with Leishmania major exogenous antigens protects susceptible...with L. major. "The potential of Leishmania major culture-derived soluble exogenous...Infection and Immunity (Immunization with Leishmania major exogenous antigens protects susceptible...
- Leishmania major secreting GM-CSF delays disease development in mice.
- Newspaper article from: Health & Medicine Week December 22, 2003 700+ words
...amp; NewsRx.net) -- Recombinant Leishmania major secreting biologically active granulocyte...vaccination, we engineered recombinant Leishmania major strains producing biologically active...Infection and Immunity (Recombinant Leishmania major secreting biologically active ...
- Phosphoglycan-deficient Leishmania major is a model for persistence studies.
- Newspaper article from: Drug Week October 24, 2003 700+ words
...A phosphoglycan negative strain of Leishmania major is capable of persisting in the mammalian...persistence are poorly understood. Leishmania major lacking phosphoglycans (lpg2...pathology in phosphoglycan-deficient Leishmania major. Science, 2003;301(5637...
- T cells mediate immunity to Leishmania major in absence of parasites.
- Newspaper article from: Life Science Weekly December 7, 2004 700+ words
...cells mediate long-term immunity to Leishmania major in the absence of persistent parasites...the United States, "Infection with Leishmania major induces a protective immune response...cells mediate long-term immunity to Leishmania major in the absence of persistent parasites...