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Roles of IgA and IgG in influenza control in respiratory tract studied.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the roles of IgA and IgG in the control of influenza viral infection in the murine respiratory tract.
According to published research from the United States, "The roles of IgG and secretory IgA in the protection of the respiratory tract (RT) against influenza infection remain unclear. Passive immunization with antibody doses resulting in serum IgG anti-influenza virus antibody titers far in excess of those observed in immune mice has compounded the problem. We compared the effects of i.v. anti-influenza virus IgG and i.v. anti-influenza virus polymeric IgA (pIgA) mAb administered in amounts designed to replicate murine convalescent serum or nasal antibody titers, respectively."
"A serum anti-influenza virus IgG titer 2.5 times the normal convalescent serum anti-influenza virus IgG titer was required for detectible antibody transudation into nasal secretions, and a serum IgG titer 7 times normal was needed to lower nasal viral shedding by 98%," reported Kathryn B. Renegar and collaborators at Vanderbilt University, the University of Florida, and the University of Memphis. "Anti-influenza virus pIgA at a nasal antibody titer comparable to that seen in convalescent mice eliminated nasal viral shedding. The RT of influenza-infected pIgA- or IgG-protected mice were studied by scanning electron microscopy."
"Only pIgA was found to prevent virally induced pathology in the upper RT, suggesting that IgG did not ...
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