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HIV-1 nef down-regulates antigen-presenting molecules.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells.
According to published research from Japan, "The effects of Nef molecules on immature dendritic cells (iDCs) were analyzed using recombinant human immunodeficiency virus type 1 (HIV-1) with intact nef gene, pseudotyped with vesicular stomatitis virus glycoprotein, HIVNSV-G/+Nef. When iDCs were infected with HIVNSV-G/+Nef, the surface expression of CD1a, a molecule for presenting glycolipid/lipid antigens, was selectively down-regulated among CD1 molecules (CD1a, -b, -c, and -d) as well as class I MHC."
"Moreover, the CD1a molecules were also down-modulated and co-localized with DsRed2-tagged-Nef in CD1a-transfected cells," said Eiji Shinya and colleagues at Nippon Medical College. "Their co-localization was dependent upon CD1a cytoplasmic tail and the CD1a was redistributed from cell surface to LAMP-1+ late endosomal/lysosomal compartment. These findings reveal that the HIV-1-Nef interferes with the intracellular trafficking of CD1a, and suggest the involvement of ...
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- HIV Nef induces DC differentiation through Vav signaling.
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- Nef binds p6* in GagPol during replication of HIV-1.
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- Characterization of Nef-CXCR4 interactions important for apoptosis induction.
- Newspaper article from: AIDS Weekly December 27, 2004 700+ words
...NewsRx.net) -- The characterization of Nef-CXCR4 interactions are important for apoptosis induction. "The HIV-1 Nef protein was analyzed for apoptotic structural...motifs were identified. One centered on Nef amino acids (aa) 50 to 60, with the...
- HIV Nef activates macrophage STAT3 via soluble factors.
- Newspaper article from: Drug Week February 13, 2004 700+ words
...NewsRx.com & NewsRx.net) -- HIV Nef activates macrophage STAT3 via soluble factor...human immunodeficiency virus-1 (HIV-1) Nef protein significantly influences the activation...Superiore di Sanita in Rome found that "Nef specifically activates STAT3 in primary...
- HIV Nef uses soluble factors to activate macrophage STAT3.
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...NewsRx.com & NewsRx.net) -- HIV Nef activates monocyte/macrophage STAT3 by...human immunodeficiency virus-1 (HIV-1) Nef protein significantly influences the activation...Istituto Superiore di Sanita found that "Nef specifically activates STAT3 in primary...
Source: HighBeam Research, HIV-1 nef down-regulates antigen-presenting molecules.