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Dendritic cell maturation drives Th1 polarization.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Dendritic cell maturation promoted by M1 and M4, end products of steroidal ginseng saponins metabolized in the digestive tract, drives Th1 polarization.
"Ginseng is a medicinal herb widely used in Asian countries, and many of its pharmacological actions are attributed to the ginsenosides. Dendritic cells (DCs) play a pivotal in the initiation of T-cell-mediated immune responses, making them an attractive cellular adjuvant for use in cancer vaccines. In this study, we investigated whether M1 and M4, end products of steroidal ginseng saponins metabolized in digestive tracts, can drive DC maturation from human monocytes in vitro," scientists in Germany report.
"Human monocytes were cultured with GM-CSF and IL-4 for 6 days, followed by another 2 days in the presence of M1, M4, or TNF-alpha as a maturation stimulus," said Masao Takei at Research Center Borstel and collaborators in Germany. "Stimulation with 20 PM of M1 or M4 increased expression level of CD80, CD83, and CD86 as expressed by mean fluorescence intensity (MFI) and decreased endocytic activity. M4-primed mature DCs also displayed enhanced T cells stimulatory capacity in a MLR, as measured by T cell proliferation."
"Mature DCs differentiated with M1 or M4 induced the differentiation of naive T cells towards a helper T cell type 1 (Th1) response at DC/T ...
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Source: HighBeam Research, Dendritic cell maturation drives Th1 polarization.