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Centrally injected GLP-1 prevents some types of gastric mucosal damage.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Centrally injected GLP-1 prevents some types of gastric mucosal damage.
According to a study from Turkey, "Glucagon-like peptide-1 (GLP-1) is accepted to be a peptide involved in the central regulation of gastrointestinal function, but its potential gastroprotective effect is not clear. The aim of this study was to investigate whether intracerebroventricularly injected GLP-1 has protective effects on gastric mucosal lesions induced by several models, and if yes, whether these effects are due to the gastric antisecretory effect of the peptide."
"GLP-1, which was injected in three different doses (1, 10, 100 ng/10 mcL; i.c.v.) to conscious rats, prevented the mucosal lesions induced by reserpine and ethanol, but did not prevent the gastric mucosal lesions induced by pyloric ligation," reported Naciye Isbil-Buyukcoskun and Guldal Gulec at Uludag University. "In addition, 1 ng/10 mcL dose of centrally injected GLP-1 inhibited gastric acid secretion in pylorus-ligated rats."
The researchers stated, "As a result, we conclude ...
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...hypothalamus, the part of the brain that scientists believe is the body's main appetite control center. Immediately after Bloom injected GLP-1 into the brains of hungry rats, the animals' appetites dropped by as much as 95 percent. GLP-1 also made the rats...
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...has the same role in people. In a study reported in Thursday's issue of the journal Nature, Bloom and his colleagues injected GLP-1 into the brains of rats. In animals that hadn't eaten in 24 hours, the injections reduced food intake by up to 95...
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...hypoglycaemic events and no weight gain," scientists in Grenoble, France report (see also Diabetes Therapy). "The subcutaneous injected GLP-1 analogues show larger reductions in HbA(1c) by 0.8-1.7% and a weight loss (1.75-3.8 kg) with most gastrointestinal...
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...1 has the same role in people. In a study reported in today's issue of the journal Nature, Bloom and his colleagues injected GLP-1 into the brains of rats. In animals that hadn't eaten in 24 hours, the injections reduced food intake by up to 95...
