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Microparticle encephalitis vaccine elicits mixed immmune response.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A cationic microparticle-adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein is immunogenic in mice.
"Previously, we described a plasmid pMEa, synthesizing the anchored form of Japanese encephalitis virus (JEV) envelope protein that generated virus-neutralizing antibodies in mice upon intra-muscular injection. The immunized mice showed significant protection against lethal JEV challenge. In order to improve the efficacy of plasmid DNA immunization against JEV, methods need to be employed that would enhance neutralizing antibody titers," researchers in India report.
"Plasmid DNA adsorbed to cationic microparticles has recently been shown to significantly improve its immunogenicity," said Rupinderjeet Kaur and colleagues at the National Institute of Immunology in New Delhi. "In the present study, we have adsorbed the plasmid pMEa on cationic microparticles and have compared its immunogenicity with the naked plasmid DNA. As seen in ELISA, the microparticle-adsorbed DNA induced higher titers of anti-JEV antibodies when compared to those induced by the naked DNA. No difference, however, was seen in JEV ...
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Source: HighBeam Research, Microparticle encephalitis vaccine elicits mixed immmune response.