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Efficacy of dendritic cell-induced tolerance dependent on delivery path.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The efficacy of peripheral tolerance induced by dendritic cells is dependent on the route of delivery.
"Previous studies have demonstrated that the route of delivery of dendritic cells (DC) is an important variable in eliciting antitumor immunity. In contrast, little is known about different routes of DC administration to influence peripheral tolerance in autoimmune diseases. Here we compared therapeutic effect of splenic IFN-gamma-modified-DC (IFN-gamma-DC) in actively induced experimental allergic encephalomyelitis (EAE) by different routes of DC delivery," scientists in Sweden report.
"Following subcutaneous (s.c.) injection, IFN-gamma-DC effectively suppressed clinical signs of EAE, whereas intravenous (i.v.) injection did not inhibit clinical signs of EAE," said Qing-Hong Zhang and colleagues at the Karolinska Institute. "Compared to s.c. injection, i.v. injection of IFN-gamma-DC failed to mediate T cell responses, but stimulated anti-MBP antibody production and upregulated pro-inflammatory IL-1beta, IFN-gamma, and TNF-alpha as well as RANTES expression which may contribute to the accumulation of inflammatory ...
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Source: HighBeam Research, Efficacy of dendritic cell-induced tolerance dependent on delivery...