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Antibodies in tumor immunotherapy reviewed.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review antibodies in tumor immunotherapy in a recent issue of Expert Opinion on Biological Therapy.
"The role of antibodies as therapeutic cancer vaccines includes two distinct approaches, which are summarized in this review, namely anti-idiotypic vaccines and antigen-antibody complex therapies. Bispecific antibodies directed against T cells or antigen-presenting cells are also referenced. The report focuses on theoretical issues, laboratory data on the mechanism of action, examples of humoral and cellular immune induction, and novel therapeutic advances in vaccine development," scientists writing in the journal Expert Opinion on Biological Therapy report.
"The biology of antigen processing and recent advances in the field of dendritic cell biology are critical to understanding the potent immune response induction," said Birgit C. Schultes and Christopher F. Nicodemus at Unither Pharmaceutical. "Future directions include combination therapies to manipulate immune regulatory mechanisms and to enhance clinical effects. Additional applications of antibodies ...
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