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Profile of continuous antigenic regions of botulinum H-chain reported.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers present the full profile of the continuous antigenic regions of the H-chain of botulinum neurotoxin A in a recent issue of the Protein Journal.
According to recent research from the United States, "Previously, we mapped the antibody (Ab) and T-cell recognition regions on the H-C domain (residues 855-1296) of the 848-residue heavy (H) chain of botulinum neurotoxin A (BoNT/A). We have mapped here the H-N-domain (residues 449-859) regions that bind protective anti-BoNT/A antibodies raised in four different species. We synthesized, purified, and characterized 29 19-residue peptides that spanned the entire H, and overlapped consecutively by 5 residues, and also region L218-231 around the L-chain's substrate-binding site."
"Human, horse, mouse, and chicken anti-BoNT/A antibodies did not bind to the L-peptide but recognized similar H-N regions within peptides 519-537/533-551/547-565/561-579 (with slight left- or right-shifts), 743-761, 785-803, and 813-831/827-845 overlap," said M. Zouhair Atassi and Behzod Z. Dolimbek at Baylor College of Medicine. "Recognition of other peptides that bound lower antibody levels showed similarities and also some differences. Peptide 463-481, strongly immunodominant with horse antisera, did not bind human, mouse, and chicken antibodies. However, peptide 449-467 bound antibodies in these three antisera, and the region may have shifted to the right (peptide 463-481) with horse antibodies."
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Source: HighBeam Research, Profile of continuous antigenic regions of botulinum H-chain reported.