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Plasmacytoid dendritic cell activation augments SIV-specific T cells.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques augments the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells.
"There are two principle subsets of dendritic cells (DCs); CD11c+CD123- myeloid DCs (MDCs) and CD11c-CD123+ plasmacytoid DCs (PDCs). DC activation via TNF-TNFRs (e.g., CD40L) and TLRs (e.g., immunostimulatory oligodeoxyribonucleotides, ISS-ODNs) is crucial for maximal stimulation of innate and adaptive immunity. Macaque DC biology is being studied to improve HIV vaccines using the SIV macaque model," researchers in the United States report.
"Using lineage (Lin) markers to exclude non-DCs, Lin-HLA-DR+CD11c+CD123- MDCs and Lin-HLA-DR+CD11c-CD123+ PDCs were identified in the blood of uninfected macaques and healthy macaques infected with SIV or simian-human immunodeficiency virus," said Natalia Teleshova at the Population Council in New York and collaborators throughout the U.S. "Overnight culture of DC-enriched Lin-depleted cells increased CD80 and CD86 expression. IL-12 production and CD80/CD86 expression by MDC/PDC mixtures was further enhanced by CD40L and ISS-ODN treatment. A CpG-B ISS-ODN increased CD80/CD86 expression by PDCs, but resulted in little IFN-alpha secretion unless IL-3 was added."
"In contrast, a CpG-C ISS-ODN and aldrithiol-2-inactivated (AT-2) SIV induced considerable PDC activation and IFN-a release without needing exogenous IL-3," reported the ...
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Source: HighBeam Research, Plasmacytoid dendritic cell activation augments SIV-specific T cells.