AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Papillomavirus-HIV-1 gp41 virus-like particles induce HIV antibodies.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Oral immunization with bovine papillomavirus-HIV-1 gp41 chimeric virus-like particles induced mucosal and systemic neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1).
"Human immunodeficiency virus type 1 (HIV-1) envelope-specific neutralizing antibodies are generated late after initial infection, and the neutralizing antibody response is weak in the infected individuals. Administration of neutralizing antibodies such as 2F5 to HIV-1-infected individuals resulted in reductions in viral loads. Because HIV-1 is transmitted mainly via mucosa and because HIV-specific neutralizing antibodies reduce HIV-1 in infected individuals, a vaccine that can induce both mucosal and systemic HIV-1-specific neutralizing antibodies may be used to prevent and to treat HIV-1 infection," scientists in the United States report.
"In this study, we made a bovine papillomavirus (BPV) L1-HIV-1 gp41 fusion protein in which ELDKWA of gp41 was inserted into the N terminus of BPV L1 (amino acids 130 to 136)," said Hongtao Zhang and colleagues at Loyola University. "Expression of the fusion protein in insect cells led to the assembly of chimeric virus-like particles (CVLPs). The CVLPs had sizes similar to those of BPV particles and were able to bind to the cell surface and penetrate the cell membrane. Oral immunization of mice with CVLPs induced gp41-specific serum immunoglobulin G (IgG) and intestinal secretory IgA."
"However, ...
- Is clearance of HIV-1 viraemia at seroconversion mediated by neutralizing...
- Newspaper article from: AIDS Weekly December 14, 1992 700+ words
...popular wisdom, neutralizing antibodies are not responsible...the clearing of HIV-1 viremia seen...demonstration that neutralizing antibodies are directly correlated...viremia in primary HIV infection. To...therapies for HIV disease should not attempt to induce ...
- Virus-cross-HIV-1-neutralizing antibodies induced by in vivo expression system.
- Newspaper article from: AIDS Weekly April 7, 2003 700+ words
...the induction of neutralizing antibodies by in vivo expression...virus type I (HIV-1) envelope...rabbits. The HIV-1 envelope...primary virus-neutralizing antibodies (donor of reference serum, HIV-1-neutralizing...
- Antigen engineering promotes induction of HIV-neutralizing antibodies.
- Newspaper article from: AIDS Vaccine Week January 19, 2004 700+ words
...promote the induction of HIV-neutralizing antibodies. According to a study...Understanding how neutralizing antibodies recognize HIV could aid the design...promote the induction of HIV-neutralizing antibodies. Trends Mol Med...
- V3-loop peptide conjugates elicit neutralizing antibodies. (HIV vaccines)
- Newspaper article from: AIDS Weekly May 2, 1994 700+ words
HIV Vaccines Relatively...peptides from the HIV*1 V3 loop bound...protein elicit neutralizing antibodies, but smaller...and induced neutralizing antibodies nearly as well...gp120 from the MN HIV*1 variant...
- Neutralizing antibodies against highly cytopathic Zairian human...
- Newspaper article from: AIDS Weekly Machado, A.A. Bakpabua, M. Salaun, D. Demareuil, J. Krchnak, V. Macgregor, R.R. Chermann, J.C. Hirsch, I. May 1, 1995 700+ words
...specific cross-reacting neutralizing antibodies against HIV-1 LAV and HIV-1 NDK...indicate that strains with an HIV-1 NDK-like serotype...presence of type-specific neutralizing antibodies against HIV-1 NDK in sera from North...
- N-linked glycan g15 in gp120 V3 loop blocks neutralizing antibodies.(HIV...
- Newspaper article from: Virus Weekly February 18, 2003 700+ words
...the role of some HIV protein components...preventing the effects of neutralizing antibodies. S. Polzer and...and R5X4 tropic HIV-1 mutants, which...involved in blocking of neutralizing antibodies and shifting HIV tropism from R5X4...
- In vitro assessment of the therapeutic potential of anti-HIV-1 monoclonal...
- Newspaper article from: AIDS Weekly Kessler, J.A. McKenna, P.M. Emini, E.A. Conley, A.J. July 3, 1995 700+ words
...D.C., "The therapeutic potential of anti-HIV-1 neutralizing antibodies was assessed using two human monoclonal antibodies...These observations suggest that certain anti-HIV-1 mAbs should be considered for possible therapeutic...
- Geneart AG, of Regensburg, Germany, entered a 300,000 [euro] (US$471,590)...
- Newspaper article from: BioWorld International March 19, 2008 700+ words
...the European Union project, titled "New HIV Vaccines Inducing Broadly Reactive Neutralizing Antibodies," which is coordinated by Paris-based...development of a broad-spectrum vaccine against HIV. Geneart develops and synthesizes the needed...
- Neutralizing antibodies against HIV-1 from combinatorial phage display...
- Newspaper article from: AIDS Weekly Parren, P.W.H.I. Earl, P.L. Moss, B. Barbas, C.F., III Burton, D.R. June 12, 1995 700+ words
...libraries were prepared from long-term HIV-1 seropositive survivors (>12 years). In initial experiments, monomeric HIV-1 envelope subunits were used for enrichment...presumably infected with a clade B strain of HIV-1, whereas the antigen for affinity selection...
- Cross-neutralizing antibodies raised by UBI HIV vaccine. (United Biomedical...
- Newspaper article from: AIDS Weekly August 29, 1994 700+ words
...Conference on AIDS The prototype for a candidate HIV vaccine has demonstrated the ability to...determinants representing international HIV*1 isolates. The prototype vaccine, however...derived from the V3 domain of the MN strain HIV*1. Barbara J. Potts of United Biomedical...
Source: HighBeam Research, Papillomavirus-HIV-1 gp41 virus-like particles induce HIV antibodies.