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Immune responses to hemagglutinin/SHIV-like particle vaccine reported.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists report Th cell-independent immune responses to a chimeric hemagglutinin/simian human immunodeficiency virus-like particle vaccine.
"CD4+ Th cells are believed to be essential for the induction of humoral and cellular immune responses. In this study we tested the effect and possible mechanisms of the major antigenic component in influenza, hemagglutinin (HA), in helping HIV Env to induce immune responses in CD4+ T cell knockout (CD4 KO) mice. Simian HIV virus-like particles (SHIV VLPs) or phenotypically mixed chimeric influenza HA/SHIV VLPs were used as immunogens to immunize CD4 KO mice either i.p. or intranasally (i.n.)," investigators in the United States report.
"We found that chimeric HA/SHIV VLPs significantly induced a greater IgG antibody response in both i.p. and i.n. immunized mice and a greater IgA antibody response in mucosal washes in i.n. immunized mice compared with SHIV VLPs," said Qizhi Yao and collaborators at Baylor College of Medicine and Emory University. "Importantly, chimeric HA/SHIV VLPs induced (approx)3-fold higher neutralizing antibody titers against HIV 89.6 than SHIV VLPs in the absence of CD4+ T cell help. There was also (approx)40% more specific lysis of the HIV Env-expressing target cells in chimeric HA/SHIV VLP-immunized than in SHIV VLP-immunized CD4 KO mouse splenocytes."
"Moreover, we have found that chimeric HA/SHIV VLPs could efficiently bind and ...
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Source: HighBeam Research, Immune responses to hemagglutinin/SHIV-like particle vaccine reported.