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Heat shock protein mediates cross-presentation of exogenous HIV antigen.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Heat shock protein mediates cross-presentation of exogenous HIV antigen on HLA class I and class II.
According to a study from the United States, "Strong CD4+ and CD8+ T cell responses are considered important immune components for controlling HIV infection, and their priming may be central to an effective HIV vaccine. We describe in this study an approach by which multiple CD4+ and CD8+ T cell epitopes are processed and presented from an exogenously added HIV-1 Gag-p 4 peptide of 32 aa complexed to heat shock protein (HSP) gp96. CD8+ T cell recognition of the HSP/peptide complex, but not the peptide alone, was inhibited by brefeldin A, suggesting an endoplasmic reticulum-dependent pathway."
"This is the first report to describe efficient processing and simultaneous presentation of overlapping class I- and class II-restricted epitopes from the same extracellularly added precursor peptide complexed to HSP," said Devi SenGupta and collaborators at Harvard University, Antigenics, Inc., and the University of Connecticut.
"Given previous reports of the strong immunogenicity of HSP/peptide complexes, the present data suggest that HSP-complexed ...
- Hazardous effects of effluent from the chrome plating industry: 70 kDa heat...
- Magazine article from: Environmental Health Perspectives Mukhopadhyay, Indranil Saxena, Daya Krishna Chowdhuri, Debapratim Kar December 1, 2003 700+ words
...concurrent with the expression pattern of the heat shock protein 70 gene (hsp70), both in larval tissues...structure and function. Among the different heat shock proteins, the stress-inducible heat shock protein 70 (Hsp70) family is the most conserved...
- New U.S. composition patent firmly solidifies Stressgen's position in heat...
- Press release article from: PR Newswire January 15, 2002 700+ words
...fusion proteins comprised of a heat shock protein fused to any antigen. Further...our position in the field of heat shock protein fusions. The pre-GATT 17...technology for developing multiple heat shock protein fusions will remain proprietary...
- Mojave Therapeutics Announces Publication on the Identification Of an Important...
- Press release article from: PR Newswire September 30, 2002 700+ words
...leader in the development of heat shock protein-based immunotherapies, announced...ways of utilizing existing heat shock protein-based vaccines as well as...increasing the effectiveness of heat shock protein vaccines and the development...
- High-throughput screening detects heat-shock protein 90 ATPase inhibitors.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...throughput screening detects heat-shock protein 90 ATPase inhibitors. "The molecular chaperone heat-shock protein 90 (HSP90) plays a key role...screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal...
- Stressgen obtains new European patent for heat shock protein fusions.(European...
- Newspaper article from: BIOTECH Patent News January 1, 2002 700+ words
...fusion proteins comprised of heat shock proteins fused to antigens...0900). Using this patented heat shock protein 'fusion' technology, Stressgen...patent received this month on our heat shock protein 'fusion' technology," said...
- Stressgen announces issuance of U.S. patent solidifying its heat shock...
- Press release article from: PR Newswire January 4, 2002 700+ words
...our technology for developing heat shock protein fusions to treat viral diseases...market a compound such as our heat shock protein fusion candidate, HspE7...research studies to evaluate its heat shock protein 'fusion' technology in the...
- Upregulated heat shock protein 70 protects against tumor growth in mice.
- Newspaper article from: Cancer Vaccine Week May 17, 2004 700+ words
...NewsRx.net) -- Upregulated heat shock protein 70 protects against tumor growth in mice. "Although heat-shock protein 70 (Hsp70) has been considered...Cancer (Forced expression of heat-shock protein 70 increases the secretion...
- Stressgen granted United States patent covering heat shock protein HspE7.
- Newspaper article from: BIOTECH Patent News February 1, 2003 700+ words
...HPV) antigen fused to a heat shock protein (Hsp), as well as DNA encoding...fuse, or covalently link, a heat shock protein with a protein antigen to create...antigen. HspE7 is a fusion of a heat shock protein and the E7 protein from HPV...
- Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity.
- Newspaper article from: Cancer Gene Therapy Week January 19, 2004 700+ words
...com & NewsRx.net) -- Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity. "Heat shock proteins (HSPs) are recognized...study in Cancer Gene Therapy (Heat shock protein 70 gene therapy combined with...
- Studies Indicate That Schisandrin B Can Induce Heat Shock Protein Production in...
- Press release article from: Business Wire June 15, 2007 700+ words
...whether Schisandrin B can induce heat shock protein production in heart tissues...protection against I-R injury. Heat shock protein is a universal cell protectant...that Schisandrin B can induce heat shock protein production in the heart, which...
Source: HighBeam Research, Heat shock protein mediates cross-presentation of exogenous HIV...