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Gag CTL-positive vaccinees recipients do not have anti-gag p17 response.
2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele did not exhibit immunodominant anti-gag p17 (SL9) responses.
According to recent research published in the Journal of Immunology, "According to a number of previous reports, control of HIV replication in humans appears to be linked to the presence of anti-HIV-1 Gag-specific CD8 responses. During the chronic phase of HIV-1 infection, up to 75% of the HIV-infected individuals who express the histocompatibility leukocyte antigen (HLA)-A*0201 recognize the Gag p17 SLYNTVATL (aa residues 77-85) epitope (SL9). However, the role of the anti-SL9 CD8 CTL in controlling HIV-1 infection remains controversial."
"In this study we determined whether the pattern of SL9 immunodominance in uninfected, HLA-A*0201 HIV vaccine recipients is similar to that seen in chronically HIV-infected subjects," said Guido Ferrari at Duke University and collaborators throughout the U.S. "The presence of anti-SL9 responses was determined using a panel of highly sensitive cellular immunoassays, including peptide:MHC tetramer binding, IFN-gamma ELISPOT, and cytokine flow cytometry. Thirteen HLA-A*0201 vaccinees with documented anti-Gag CD8 CTL reactivities were tested, and none had a detectable anti-SL9 response."
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Source: HighBeam Research, Gag CTL-positive vaccinees recipients do not have anti-gag p17...