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What You Don't Know About Fat; Fat Cells: The average person has 40 billion of them. They multiply, they're almost impossible to kill and they're sending messages to your body that can ruin your health.(Cover Story)

Newsweek International

| September 20, 2004 | COPYRIGHT 2004 Newsweek, Inc. All rights reserved. Any reuse, distribution or alteration without express written permission of Newsweek is prohibited. For permission: www.newsweek.com. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Byline: Anne Underwood and Jerry Adler (Graphic by Anne Underwood, Kevin Hand and Josh Ulick)

It was one of the biggest medical stories of the 1990s and, consequently, one of the biggest disappointments. In 1994, researchers at Rockefeller University in New York, working with mutant mice that grew to be three times the size of normal ones, discovered what made them different: the absence of a hormone they named "leptin." When injected with leptin the mice suddenly began eating less and shedding those unsightly grams. Not since Charles Atlas had there been such a convincing set of before-and-after pictures; to millions of people who secretly identified with the ...

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