Acquired protein-S deficiency - correlation with advanced disease in HIV-1-infected patients. (Periodical Report)

SOURCE: Journal of Acquired Immune Deficiency Syndromes, May 1992;5(5):484-489.

Plasma levels of unbound protein S are decreased in individuals with HIV infection and decline as HIV disease progresses, a French study indicates.

Protein S is a vitamin K-dependent plasma protein that inhibits coagulation and enhances vitamin C activities. Some 60 percent of circulating protein S is reversibly bound to the C(4)b-binding protein of the complement system; the remainder exists as a biologically active free protein.

INSERM researchers Francois Bissuel, Christian Trepo and colleagues analyzed blood samples from 63 subjects with HIV infection (26 …