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SOURCE: Journal of Acquired Immune Deficiency Syndromes, April 1992;5(4):359-364.
The polymerase chain reaction (PCR) technique can be used to determine the susceptibility of virtually any patient isolate of HIV-1 to zidovudine (AZT), a French study indicates.
Pitie-Salpetriere Hospital researchers Magdelena Jung, Henri Agut, and colleagues evaluated the ability of PCR to predict AZT susceptibility in 13 HIV-1 isolates obtained via coculture with peripheral blood lymphocytes (PBL).
In vitro tests established that seven virus isolates from untreated subjects and four of six isolates from AZT-treated subjects were susceptible to AZT. The …