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SOURCE: Infection and Immunity, April 1992;60(4):1279-1284.
Tumor necrosis factor alpha (TNF-alpha) appears to be an important factor in host resistance to Pneumocystis carinii infection, murine studies show.
W.X. Chen and colleagues of Trudeau Institute Inc., Saranac Lake, New York, note that severe combined immunodeficient (SCID) mice that acquire natural pulmonary infection with P. carinii can clear this infection after receiving immune reconstitution with spleen cells from immunocompetent mice.
Using this system as a model for human Pneumocystis carinii pneumonia (PCP), Chen et al. examined the roles of TNF-alpha and gamma interferon …